Cas no 1257293-83-6 (1-(azetidin-3-yl)-4,4-difluoropiperidine)

1-(Azetidin-3-yl)-4,4-difluoropiperidine is a heterocyclic compound featuring both azetidine and piperidine moieties, with difluorination at the 4-position of the piperidine ring. This structure imparts unique physicochemical properties, including enhanced metabolic stability and improved lipophilicity, making it a valuable intermediate in medicinal chemistry. The azetidine ring contributes to conformational rigidity, while the difluoropiperidine moiety can influence bioavailability and binding affinity. This compound is particularly useful in the synthesis of bioactive molecules, such as kinase inhibitors or CNS-targeting agents, where fluorine substitution is leveraged for optimal pharmacokinetic profiles. Its versatility and structural features make it a promising scaffold for drug discovery and development.
1-(azetidin-3-yl)-4,4-difluoropiperidine structure
1257293-83-6 structure
Product Name:1-(azetidin-3-yl)-4,4-difluoropiperidine
CAS No:1257293-83-6
MF:C8H14F2N2
MW:176.206968784332
MDL:MFCD22123272
CID:1005815
PubChem ID:59605315
Update Time:2025-06-07

1-(azetidin-3-yl)-4,4-difluoropiperidine Chemical and Physical Properties

Names and Identifiers

    • 1-(AZETIDIN-3-YL)-4,4-DIFLUOROPIPERIDINE
    • Piperidine, 1-(3-azetidinyl)-4,4-difluoro-
    • 1-(3-Azetidinyl)-4,4-difluoro-piperidine
    • 3-(4,4-DIFLUOROPIPERIDIN-1-YL)AZETANE
    • 3-(4,4-DIFLUOROPIPERIDIN-1-YL)AZETIDINE
    • AGN-PC-0D0PTH
    • PB27290
    • SureCN2272753
    • SCHEMBL2272753
    • DTXSID601278842
    • 1-Azetidin-3-yl-4,4-difluoropiperidine
    • 1257293-83-6
    • AS-78823
    • EN300-3004021
    • 1-(3-Azetidinyl)-4,4-difluoropiperidine
    • AKOS024015618
    • CS2208
    • CS-0036636
    • C8H14F2N2
    • 3-(4,4-DIFLUOROPIPERIDIN-1-YL)AZETANE;
    • MFCD22123272
    • A1-24206
    • AMY5494
    • DB-406529
    • 1-(azetidin-3-yl)-4,4-difluoro-piperidine
    • A889969
    • 1-(azetidin-3-yl)-4,4-difluoropiperidine
    • MDL： MFCD22123272
    • Inchi： 1S/C8H14F2N2/c9-8(10)1-3-12(4-2-8)7-5-11-6-7/h7,11H,1-6H2
    • InChI Key： OIQJXEUDXZJIRR-UHFFFAOYSA-N
    • SMILES： FC1(CCN(CC1)C1CNC1)F

Computed Properties

  • Exact Mass: 176.11250478g/mol
  • Monoisotopic Mass: 176.11250478g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 1
  • Complexity: 158
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.8
  • Topological Polar Surface Area: 15.3?2

1-(azetidin-3-yl)-4,4-difluoropiperidine Pricemore >>

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Alichem
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Piperidine,1-(3-azetidinyl)-4,4-difluoro
 1257293-83-6 95%
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CS20004-1 G
1-(azetidin-3-yl)-4,4-difluoropiperidine
 1257293-83-6 97%
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CS20004-5 G
1-(azetidin-3-yl)-4,4-difluoropiperidine
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CS20004-10 G
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 1257293-83-6 97%
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 ￥ 5,148.00 2021-05-07

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