• 1. Enantiomorphic symmetry breaking in crystallization of molten sodium chlorate?
  Martin R. Ward,Gary W. Copeland,Andrew J. Alexander Chem. Commun., 2010,46, 7634-7636
• 2. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 5. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555

4-Chloro-1,8-Naphthyridine-3-Carboxylic Acid (CAS No. 1256826-20-6): A Comprehensive Overview

4-Chloro-1,8-naphthyridine-3-carboxylic acid is a chemically synthesized compound with the CAS registry number 1256826-20-6. This compound belongs to the class of naphthyridines, which are heterocyclic aromatic compounds with a fused bicyclic structure consisting of a benzene ring and a pyridine ring. The presence of the chloro group at the 4-position and the carboxylic acid group at the 3-position imparts unique chemical properties to this molecule, making it a subject of interest in various fields of research and application.

The naphthyridine core of this compound is known for its structural rigidity and aromaticity, which contribute to its stability and reactivity in different chemical environments. The chloro substituent at the 4-position introduces electron-withdrawing effects, which can influence the electronic properties of the molecule. This substitution pattern is often exploited in medicinal chemistry to modulate bioavailability, solubility, and pharmacokinetic profiles of drug candidates.

Recent studies have highlighted the potential of 4-chloro-1,8-naphthyridine-3-carboxylic acid as a building block in the synthesis of advanced materials. For instance, researchers have explored its use in constructing coordination polymers and metal-organic frameworks (MOFs) due to its ability to coordinate with metal ions. These materials exhibit promising applications in gas storage, catalysis, and sensing technologies.

In the field of pharmacology, this compound has been investigated for its potential as a lead molecule in drug discovery. Its naphthyridine skeleton has been linked to various biological activities, including anti-inflammatory, anticancer, and antimicrobial properties. A study published in *Journal of Medicinal Chemistry* demonstrated that derivatives of this compound exhibit selective inhibition against certain enzymes involved in inflammatory pathways.

The synthesis of 4-chloro-1,8-naphthyridine-3-carboxylic acid typically involves multi-step reactions starting from naphthalene derivatives. One common approach includes chlorination followed by oxidation and cyclization steps to form the naphthyridine ring system. The carboxylic acid group is introduced via oxidation or hydrolysis reactions depending on the starting material.

From an analytical standpoint, this compound can be characterized using various spectroscopic techniques such as UV-Vis spectroscopy, IR spectroscopy, and NMR spectroscopy. High-resolution mass spectrometry (HRMS) is often employed to confirm its molecular formula and purity.

Recent advancements in computational chemistry have enabled researchers to predict the electronic properties and reactivity of 4-chloro-1,8-naphthyridine-3-carboxylic acid using density functional theory (DFT) calculations. These studies provide insights into its potential interactions with biological targets and its suitability for specific applications.

In conclusion, 4-chloro-1,8-naphthyridine-3-carboxylic acid (CAS No. 1256826-20-6) is a versatile compound with a wide range of applications across multiple disciplines. Its unique chemical structure and functional groups make it an attractive candidate for further research and development in areas such as drug discovery, materials science, and chemical synthesis.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)