• 1. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 2. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 3. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 4. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 5. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962

Comprehensive Guide to 6-Chloro-4-methoxy-3-pyridinamine (CAS No. 1256805-54-5): Properties, Applications, and Market Insights

6-Chloro-4-methoxy-3-pyridinamine (CAS No. 1256805-54-5) is a specialized pyridine derivative with growing significance in pharmaceutical and agrochemical research. This compound, characterized by its chloro and methoxy functional groups, serves as a key intermediate in the synthesis of bioactive molecules. Its unique structural features make it valuable for designing drug candidates and crop protection agents, aligning with current industry demands for novel chemical entities.

The molecular structure of 6-chloro-4-methoxy-3-pyridinamine combines a pyridine ring with strategic substitutions at the 3, 4, and 6 positions. This arrangement influences its electronic properties and reactivity patterns, making it particularly useful in heterocyclic chemistry. Researchers frequently explore its potential in medicinal chemistry, where modified pyridine cores are crucial for developing kinase inhibitors and central nervous system (CNS) active compounds – two trending areas in drug discovery.

In pharmaceutical applications, CAS 1256805-54-5 demonstrates versatility as a building block for small molecule therapeutics. Recent studies highlight its incorporation into compounds targeting inflammatory pathways and metabolic disorders, addressing prevalent health concerns like diabetes and autoimmune diseases. The compound's methoxy group enhances metabolic stability, while the chloro substituent facilitates further functionalization – features highly valued in structure-activity relationship (SAR) studies.

The agrochemical sector utilizes 6-chloro-4-methoxy-3-pyridinamine in developing next-generation pesticides and herbicides. With increasing global focus on sustainable agriculture and reduced environmental impact, this compound contributes to formulations with improved selectivity and lower toxicity profiles. Its structural motifs appear in compounds showing activity against resistant pest strains, addressing the critical challenge of pesticide resistance in modern farming.

From a synthetic chemistry perspective, 1256805-54-5 offers multiple advantages. The amino group at position 3 serves as an excellent handle for amide formation or reductive amination, while the chloro substituent enables cross-coupling reactions such as Suzuki or Buchwald-Hartwig couplings. These characteristics make it a preferred choice for parallel synthesis and combinatorial chemistry approaches, accelerating drug discovery workflows.

Market analysis indicates growing demand for 6-chloro-4-methoxy-3-pyridinamine, particularly from contract research organizations (CROs) and specialty chemical manufacturers. The compound's applications in developing precision medicines and green chemistry solutions align with current industry megatrends. Suppliers are expanding production capabilities to meet requirements from both pharmaceutical and agrochemical innovators, with quality specifications becoming increasingly stringent.

Quality control of CAS 1256805-54-5 involves rigorous analytical protocols. High-performance liquid chromatography (HPLC) typically verifies purity levels exceeding 98%, while mass spectrometry and nuclear magnetic resonance (NMR) confirm structural integrity. These quality assurances are critical for researchers requiring reproducible results in high-throughput screening and lead optimization processes.

Storage and handling recommendations for 6-chloro-4-methoxy-3-pyridinamine emphasize protection from moisture and light, typically suggesting ambient temperature storage in sealed containers. While not classified as hazardous under standard regulations, proper laboratory practices should be followed when working with this fine chemical, including use of appropriate personal protective equipment.

The future outlook for 1256805-54-5 remains positive, driven by expanding research into targeted therapies and sustainable agrochemicals. As synthetic methodologies advance, new derivatives of this pyridine amine continue to emerge, finding applications in diverse fields including material science and catalysis. Ongoing patent activity suggests sustained interest from major pharmaceutical companies, indicating its potential role in future blockbuster drug development.

For researchers sourcing 6-chloro-4-methoxy-3-pyridinamine, key considerations include supplier reliability, batch-to-batch consistency, and technical support. Reputable suppliers provide comprehensive certificates of analysis and material safety data sheets, along with custom synthesis options for modified versions of this versatile chemical building block.

• 943632-50-6(3-(2-Chloropyridin-4-yloxy)aniline)
• 849743-71-1(3-Pyridinamine, 4-(4-chlorophenoxy)-)
• 872282-68-3(6-Chloro-4-ethoxypyridin-3-amine)
• 173435-35-3(2-chloro-4-ethoxypyridin-3-amine)
• 630125-70-1(4-(2-Chloro-pyridin-4-yloxy)-phenylamine)
• 75711-01-2(6-Chloro-5-methoxypyridin-3-amine)
• 1227586-39-1(2-Chloro-5-methoxypyridin-4-amine)
• 173435-34-2(2-chloro-4-methoxy-pyridin-3-amine)
• 120256-14-6(4-methoxy-3-Pyridinamine hydrochloride)
• 1269293-72-2(5-amino-2-chloropyridin-4-ol hydrochloride)