• 1. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 2. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 3. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
• 4. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 5. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210

Exploring Ethyl 3-(4-Isobutylphenyl)acrylate (CAS No. 1256636-24-4): Properties, Applications, and Industry Insights

Ethyl 3-(4-Isobutylphenyl)acrylate (CAS No. 1256636-24-4) is a specialized organic compound gaining attention in pharmaceutical and fine chemical industries. This ester derivative, characterized by its isobutylphenyl and acrylate functional groups, exhibits unique reactivity and solubility profiles. Researchers are increasingly exploring its potential as a building block for drug discovery, particularly in non-steroidal anti-inflammatory drug (NSAID) analogs, owing to its structural similarity to ibuprofen precursors.

The compound's molecular structure features an ethyl ester group conjugated to an aromatic system, making it valuable for cross-coupling reactions in synthetic chemistry. Recent studies highlight its utility in polymer modification, where the acrylate moiety enables UV-curable applications. With melting points ranging between 45-50°C and solubility in common organic solvents like ethyl acetate and dichloromethane, it offers practical handling advantages for industrial processes.

Current market trends show growing demand for high-purity Ethyl 3-(4-Isobutylphenyl)acrylate, driven by its role in developing targeted therapeutics. Analytical techniques such as HPLC and GC-MS are critical for quality control, with purity standards often exceeding 98% for pharmaceutical applications. The compound's stability under nitrogen atmosphere makes it suitable for long-term storage, addressing common concerns about chemical degradation in research settings.

Environmental considerations have prompted investigations into green synthesis routes for CAS No. 1256636-24-4. Recent patents describe catalytic methods reducing byproduct formation, aligning with sustainable chemistry initiatives. Its low aquatic toxicity profile, as evidenced by OECD 210 testing, positions it favorably compared to traditional acrylate derivatives in regulatory assessments.

In material science, the compound's photopolymerization kinetics are being studied for advanced coating formulations. The isobutyl substituent enhances compatibility with hydrophobic matrices, making it valuable for water-resistant adhesives. These applications respond to industry needs for high-performance materials in automotive and electronics sectors, where search data shows increasing queries about specialty acrylates.

Quality specifications typically include parameters like residual solvent content (often limited to <500 ppm) and isomeric purity. Advanced purification techniques such as preparative chromatography ensure batch-to-batch consistency, a critical factor for GMP-compliant production. The compound's chromatographic behavior has been extensively documented to facilitate method development in analytical laboratories.

Emerging research explores the compound's potential in bioconjugation chemistry, particularly for prodrug development. Its ester hydrolysis characteristics under physiological conditions make it interesting for controlled release formulations, addressing frequent searches about drug delivery systems. Computational studies of its molecular interactions with biological targets are contributing to structure-activity relationship databases.

From a regulatory perspective, Ethyl 3-(4-Isobutylphenyl)acrylate falls under standard chemical handling guidelines. Safety data sheets emphasize proper ventilation during handling and recommend PPE including nitrile gloves, reflecting workplace safety trends. Its flammability classification (typically Category 4) requires standard flammable storage cabinets in industrial settings.

The compound's spectroscopic fingerprints (including characteristic IR stretches at 1715 cm?1 for carbonyl and 1630 cm?1 for alkene) serve as important quality markers. Recent advances in process analytical technology (PAT) enable real-time monitoring of its synthesis, responding to industry demands for Industry 4.0 chemical manufacturing solutions.

Market analysts note steady growth in the custom synthesis sector for CAS No. 1256636-24-4, with projected CAGR of 6.2% through 2028. This reflects broader trends in tailor-made intermediates for niche applications. The compound's scalable production potential makes it attractive for contract manufacturing organizations (CMOs) specializing in small molecule APIs.

• 105393-26-8(2-Propenoic acid, 3-[4-(1,1-dimethylethyl)phenyl]-, ethyl ester)
• 144756-64-9(2-Propenoic acid, 3-bicyclo[4.2.0]octa-1,3,5-trien-3-yl-, ethyl ester, (E)-)
• 32580-69-1(Ethyl 3-(4-isopropylphenyl)acrylate)
• 62713-10-4(2-Pentenoic acid, 4-methyl-3-phenyl-, ethyl ester, (2E)-)
• 158010-17-4(ethyl (2E)-3-(4-tert-butylphenyl)prop-2-enoate)
• 723304-09-4(ethyl (2E)-3-(4-ethylphenyl)prop-2-enoate)
• 290311-72-7(2-Propenoic acid, 3-phenyl-, 3-phenylpropyl ester, (2E)-)
• 94201-33-9(2-Propenoic acid,3-[3,5-bis(1-methylethyl)phenyl]-, ethyl ester)
• 122-68-9(3-Phenylpropyl cinnamate)
• 62751-30-8(ethyl (2Z)-4-methyl-3-phenylpent-2-enoate)