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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Phenylpyridines

Comprehensive Overview of 6-(2-Methoxyphenyl)pyridin-3-ol (CAS No. 1255638-36-8): Properties, Applications, and Research Insights

6-(2-Methoxyphenyl)pyridin-3-ol (CAS No. 1255638-36-8) is a specialized organic compound gaining attention in pharmaceutical and material science research. This heterocyclic derivative combines a pyridine core with a methoxyphenyl substituent, offering unique electronic and steric properties. Recent studies highlight its potential as a building block for drug discovery, particularly in designing kinase inhibitors and GPCR-targeted therapeutics, aligning with the growing demand for precision medicine approaches.

The compound's molecular structure (C₁₂H₁₁NO₂) features a hydrogen bond donor/acceptor configuration, making it valuable for molecular docking studies. Researchers are exploring its role in bioisosteric replacements, a trending topic in medicinal chemistry optimization. Its logP value (~2.1) and polar surface area (49.3 ?2) suggest favorable blood-brain barrier permeability, relevant to neurotherapeutic development – a hot sector receiving 47% more PubMed citations in 2023 compared to 2020.

In material science, the conjugated π-system of 6-(2-Methoxyphenyl)pyridin-3-ol enables applications in organic electronics. Its fluorescence properties are being investigated for OLED emitters and sensor materials, coinciding with the global push for energy-efficient displays (projected $88 billion market by 2027). The methoxy group enhances solubility while maintaining thermal stability, addressing key challenges in solution-processable organic semiconductors.

Synthetic protocols for CAS 1255638-36-8 typically involve Pd-catalyzed cross-coupling or microwave-assisted synthesis, reflecting industry shifts toward green chemistry principles. Analytical characterization via LC-MS and NMR spectroscopy confirms its high purity (>98%), crucial for structure-activity relationship studies. Recent patent analyses show a 22% annual increase in filings incorporating similar biaryl scaffolds, underscoring its strategic importance.

Environmental and ADMET profiling data indicate this compound exhibits favorable metabolic stability profiles in preclinical models. Its low cytotoxicity (CC₅₀ >100 μM in HepG2 cells) supports potential therapeutic index advantages. These properties align with current fragment-based drug design trends, where researchers prioritize lead-like molecules with balanced physicochemical properties.

From a commercial perspective, 6-(2-Methoxyphenyl)pyridin-3-ol serves as a high-value intermediate for contract research organizations. Market intelligence reveals growing procurement by biotech startups focusing on neurodegenerative disease targets and age-related disorders – therapeutic areas attracting $3.4 billion in venture funding last year alone. Its shelf stability under controlled conditions (-20°C, argon) ensures reliable supply chain performance.

Emerging applications include its use as a ligand precursor in transition metal catalysis, particularly for C-H activation reactions gaining traction in sustainable synthesis methodologies. The compound's chelation capacity enables novel catalyst design, with recent ACS publications demonstrating 12-15% yield improvements in asymmetric hydrogenation when using derived complexes.

Quality control standards for CAS 1255638-36-8 typically require HPLC purity verification and residual solvent analysis per ICH guidelines. Advanced polymorph screening techniques (DSC, PXRD) confirm its crystalline form stability, critical for formulation development. These rigorous specifications reflect the compound's positioning in preclinical development pipelines rather than just exploratory research.

Future research directions may explore its photophysical tuning through structural modifications, potentially creating multicolor emitters for bioimaging probes. Computational studies suggest the hydroxyl group offers sites for prodrug derivatization, an approach increasingly used to enhance drug delivery in targeted therapies. These developments position 6-(2-Methoxyphenyl)pyridin-3-ol as a versatile scaffold bridging multiple scientific disciplines.

• 134948-96-2(Isoquinoline, 1-(2-methoxyphenyl)-)
• 1255638-05-1(6-(2-Methoxy-5-methylphenyl)pyridin-3-ol)
• 98061-25-7(Pyridine, 2-(2,6-dimethoxyphenyl)-)
• 922511-79-3(Pyridine, 2-(2-methoxy-1-naphthalenyl)-)
• 5957-89-1(Pyridine, 2-(2-methoxyphenyl)-)
• 1255636-26-0(6-(4-Methoxy-3-methylphenyl)pyridin-3-ol)
• 666735-10-0(Isoquinoline, 6-methoxy-7-(2-pyridinyl)-)
• 1261895-74-2(2-(2-Methoxy-5-methylphenyl)pyridin-3-ol)
• 195813-55-9(Pyridine, 2,6-bis(2-methoxyphenyl)-)
• 53698-49-0(Pyridine, 3-methoxy-2-phenyl-)