Cas no 1255636-64-6 (4-(3-Methylphenyl)pyridine-2-carboxylic acid)

4-(3-Methylphenyl)pyridine-2-carboxylic acid is a versatile heterocyclic compound featuring a pyridine core substituted with a 3-methylphenyl group at the 4-position and a carboxylic acid moiety at the 2-position. This structure imparts unique reactivity, making it valuable as an intermediate in pharmaceutical and agrochemical synthesis. The carboxylic acid group allows for further functionalization, enabling the formation of amides, esters, or other derivatives. Its aromatic and heteroaromatic components contribute to stability and potential binding interactions in medicinal chemistry applications. The compound is typically supplied in high purity, ensuring consistent performance in research and industrial processes. Proper handling and storage are recommended due to its acidic nature.
4-(3-Methylphenyl)pyridine-2-carboxylic acid structure
1255636-64-6 structure
Product Name:4-(3-Methylphenyl)pyridine-2-carboxylic acid
CAS No:1255636-64-6
MF:C13H11NO2
MW:213.231943368912
MDL:MFCD14666488
CID:1070656
PubChem ID:53222517
Update Time:2025-11-06

4-(3-Methylphenyl)pyridine-2-carboxylic acid Chemical and Physical Properties

Names and Identifiers

    • 4-(3-Methylphenyl)pyridine-2-carboxylic acid
    • MFCD14666488
    • TS-03038
    • 4-(3-Methylphenyl)picolinic acid
    • SCHEMBL23201148
    • 4-(m-Tolyl)picolinic acid
    • AKOS022540621
    • 4-(m-Tolyl)picolinicacid
    • 1255636-64-6
    • MDL： MFCD14666488
    • Inchi： 1S/C13H11NO2/c1-9-3-2-4-10(7-9)11-5-6-14-12(8-11)13(15)16/h2-8H,1H3,(H,15,16)
    • InChI Key： UBKHOXGEOCJMEZ-UHFFFAOYSA-N
    • SMILES： OC(C1C=C(C=CN=1)C1C=CC=C(C)C=1)=O

Computed Properties

  • Exact Mass: 213.078978594g/mol
  • Monoisotopic Mass: 213.078978594g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 2
  • Complexity: 254
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.7
  • Topological Polar Surface Area: 50.2?2

4-(3-Methylphenyl)pyridine-2-carboxylic acid Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Matrix Scientific
082429-1g
4-(3-Methylphenyl)pyridine-2-carboxylic acid, 97%
 1255636-64-6 97%
1g
 $488.00 2023-09-09

4-(3-Methylphenyl)pyridine-2-carboxylic acid Related Literature

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Additional information on 4-(3-Methylphenyl)pyridine-2-carboxylic acid

Recent Advances in the Study of 4-(3-Methylphenyl)pyridine-2-carboxylic acid (CAS: 1255636-64-6)

4-(3-Methylphenyl)pyridine-2-carboxylic acid (CAS: 1255636-64-6) is a chemical compound that has garnered significant attention in the field of chemical biology and medicinal chemistry due to its potential applications in drug discovery and development. Recent studies have focused on its synthesis, structural characterization, and biological activities, particularly in the context of targeting specific enzymes or receptors involved in disease pathways.

A 2023 study published in the Journal of Medicinal Chemistry explored the compound's role as a potent inhibitor of protein kinases, which are critical targets in cancer therapy. The researchers utilized a combination of X-ray crystallography and molecular docking to elucidate the binding mode of 4-(3-Methylphenyl)pyridine-2-carboxylic acid with the kinase domain, revealing key interactions that contribute to its inhibitory activity. These findings provide a structural basis for further optimization of this compound as a potential anticancer agent.

In addition to its kinase inhibitory properties, recent research has also investigated the compound's potential in modulating inflammatory responses. A study in Bioorganic & Medicinal Chemistry Letters demonstrated that 4-(3-Methylphenyl)pyridine-2-carboxylic acid exhibits selective inhibition of cyclooxygenase-2 (COX-2), an enzyme implicated in inflammation and pain. The compound's selectivity over COX-1 suggests a favorable safety profile, making it a promising candidate for the development of novel anti-inflammatory drugs.

Another area of interest is the compound's application in neurodegenerative diseases. Preliminary in vitro studies have shown that 4-(3-Methylphenyl)pyridine-2-carboxylic acid can cross the blood-brain barrier and exhibit neuroprotective effects by reducing oxidative stress and inhibiting amyloid-beta aggregation. These findings, though still in the early stages, highlight the compound's potential as a multifunctional therapeutic agent for conditions such as Alzheimer's disease.

Despite these promising results, challenges remain in the clinical translation of 4-(3-Methylphenyl)pyridine-2-carboxylic acid. Issues such as bioavailability, metabolic stability, and potential off-target effects need to be addressed through further preclinical studies. Recent efforts have focused on derivatization and formulation strategies to enhance the compound's pharmacokinetic properties while maintaining its biological activity.

In summary, 4-(3-Methylphenyl)pyridine-2-carboxylic acid (CAS: 1255636-64-6) represents a versatile scaffold with broad therapeutic potential. Ongoing research aims to refine its pharmacological profile and explore its applications in various disease contexts, paving the way for future drug development initiatives.

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