• 1. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 2. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidazopyridines Imidazopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidazopyridines

Comprehensive Overview of 2-{6-bromo-1H-imidazo[4,5-b]pyridin-2-yl}propan-2-ol (CAS No. 1250170-05-8)

2-{6-bromo-1H-imidazo[4,5-b]pyridin-2-yl}propan-2-ol (CAS No. 1250170-05-8) is a specialized organic compound that has garnered significant attention in pharmaceutical and biochemical research. This brominated imidazopyridine derivative is known for its unique structural properties and potential applications in drug discovery. The compound's molecular formula is C₉H₁₀BrN₃O, with a molecular weight of approximately 256.10 g/mol. Its distinct imidazo[4,5-b]pyridine core makes it a valuable scaffold for designing novel therapeutic agents.

In recent years, the demand for imidazo[4,5-b]pyridine derivatives has surged due to their role in targeting various biological pathways. Researchers are particularly interested in 2-{6-bromo-1H-imidazo[4,5-b]pyridin-2-yl}propan-2-ol for its potential as a kinase inhibitor or modulator of protein-protein interactions. The bromine substituent at the 6-position enhances its reactivity, making it a versatile intermediate in synthetic chemistry. This compound is often utilized in the development of small-molecule drugs, especially in oncology and neurology research.

The synthesis of 2-{6-bromo-1H-imidazo[4,5-b]pyridin-2-yl}propan-2-ol typically involves multi-step organic reactions, including condensation and bromination processes. Its purity and stability are critical for experimental reproducibility, and advanced analytical techniques such as HPLC and NMR are employed for quality control. Given its imidazo[4,5-b]pyridine backbone, this compound exhibits moderate solubility in polar organic solvents like DMSO and methanol, which is advantageous for biological assays.

One of the trending topics in pharmaceutical research is the exploration of heterocyclic compounds for treating rare diseases. 2-{6-bromo-1H-imidazo[4,5-b]pyridin-2-yl}propan-2-ol aligns with this focus, as its structure is amenable to modifications that can enhance bioavailability and target specificity. Additionally, the rise of AI-driven drug discovery has increased the demand for such building blocks, as they are frequently used in virtual screening and combinatorial chemistry.

From a commercial perspective, CAS No. 1250170-05-8 is available through specialized chemical suppliers, often in milligram to gram quantities for research purposes. Its pricing varies depending on purity and supplier, but it is generally considered a high-value intermediate due to its niche applications. Researchers frequently search for "buy 2-{6-bromo-1H-imidazo[4,5-b]pyridin-2-yl}propan-2-ol" or "CAS 1250170-05-8 suppliers," highlighting the compound's relevance in the scientific community.

In conclusion, 2-{6-bromo-1H-imidazo[4,5-b]pyridin-2-yl}propan-2-ol represents a promising candidate for advancing medicinal chemistry. Its structural features and functional groups make it a valuable tool for designing next-generation therapeutics. As the pharmaceutical industry continues to explore imidazo[4,5-b]pyridine derivatives, this compound is likely to remain a focal point in cutting-edge research.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)