• 1. An antimonate pyrochlore (H1.23Sr0.45SbO3.48) for photocatalytic oxidation of benzene: effective oxygen usage and excellent activity?
  Jing Chen,Yu Shao,Danzhen Li J. Mater. Chem. A, 2017,5, 937-941
• 2. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 3. An integrated system for field analysis of Cd(ii) and Pb(ii) via preconcentration using nano-TiO2/cellulose paper composite and subsequent detection with a portable X-ray fluorescence spectrometer?
  Xiaofeng Lin RSC Adv., 2016,6, 9002-9006
• 4. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 5. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554

Comprehensive Guide to 1-(4-Methyl-3-nitrophenyl)ethane-1-sulfonyl chloride (CAS 1247573-72-3): Properties, Applications, and Market Insights

1-(4-Methyl-3-nitrophenyl)ethane-1-sulfonyl chloride (CAS 1247573-72-3) is a specialized sulfonyl chloride derivative with significant applications in pharmaceutical and chemical research. This compound, characterized by its nitrophenyl and sulfonyl chloride functional groups, serves as a key intermediate in the synthesis of various bioactive molecules. Its unique structure makes it valuable for drug discovery and material science, aligning with current trends in green chemistry and sustainable synthesis.

The molecular formula of 1-(4-Methyl-3-nitrophenyl)ethane-1-sulfonyl chloride is C₉H₁₀ClNO₄S, with a molecular weight of 263.7 g/mol. Its sulfonyl chloride group (-SO₂Cl) is highly reactive, enabling it to participate in nucleophilic substitution reactions, a feature widely exploited in peptide coupling and polymer chemistry. Researchers frequently search for "sulfonyl chloride applications" or "nitrophenyl derivatives in drug synthesis," highlighting its relevance in modern laboratories.

In pharmaceutical applications, 1-(4-Methyl-3-nitrophenyl)ethane-1-sulfonyl chloride is utilized as a building block for small molecule inhibitors and protease-targeting drugs. Its electron-withdrawing nitro group enhances the reactivity of adjacent positions, making it ideal for constructing heterocyclic compounds. Recent studies emphasize its role in developing anticancer agents and anti-inflammatory drugs, addressing growing demand for targeted therapies.

The compound's stability under controlled conditions and compatibility with microwave-assisted synthesis (a trending topic in organic chemistry optimization) further boosts its utility. Laboratories focusing on high-throughput screening often seek "CAS 1247573-72-3 suppliers" or "sulfonation reagents for medicinal chemistry," reflecting its niche yet critical role.

From an industrial perspective, 1-(4-Methyl-3-nitrophenyl)ethane-1-sulfonyl chloride aligns with the shift toward atom-efficient synthesis. Its use in catalysis and ligand design supports the development of environmentally benign processes, a priority for pharmaceutical manufacturers complying with REACH regulations. Market analyses indicate rising interest in "specialty sulfonylating agents" and "nitroaromatic intermediates," driven by advancements in bioconjugation techniques.

Handling this compound requires standard laboratory safety protocols, including the use of anhydrous conditions and inert atmospheres to preserve its reactivity. While not classified as hazardous under normal use, proper storage in moisture-free environments is essential—a point frequently queried as "stability of sulfonyl chlorides" in scientific forums.

In summary, 1-(4-Methyl-3-nitrophenyl)ethane-1-sulfonyl chloride (CAS 1247573-72-3) exemplifies the intersection of structural versatility and practical utility in modern chemistry. Its applications span drug development, materials engineering, and process chemistry, making it a compound of enduring interest. As research trends evolve toward precision synthesis and functional materials, this sulfonyl chloride derivative will likely remain a staple in innovative chemical workflows.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)