• 1. An approach to asymmetric synthesis of β-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement?
  Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
• 2. An investigation on the interaction modes of a single-strand DNA aptamer and RBP4 protein: a molecular dynamic simulations approach?
  Raheleh Torabi,Hedayatollah Ghourchian,Massoud Amanlou Org. Biomol. Chem., 2016,14, 8141-8153
• 3. An insight into the origin of room-temperature ferromagnetism in SnO2 and Mn-doped SnO2 quantum dots: an experimental and DFT approach?
  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 4. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 5. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279

Introduction to 2-(1-methyl-1H-pyrazol-4-yl)propan-2-ol (CAS No. 1247411-50-2)

2-(1-methyl-1H-pyrazol-4-yl)propan-2-ol, with the CAS number 1247411-50-2, is a synthetic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as Methylpyrazolylpropanol, is characterized by its unique structural features, which include a 1-methylpyrazole moiety attached to a propan-2-ol backbone. These structural elements contribute to its diverse biological activities and potential therapeutic applications.

The chemical structure of 2-(1-methyl-1H-pyrazol-4-yl)propan-2-ol can be represented as follows: C₈H₁₃N₃O. The compound is a colorless liquid with a molecular weight of approximately 159.20 g/mol. Its solubility in water is limited, but it is soluble in common organic solvents such as ethanol and dimethyl sulfoxide (DMSO). These properties make it suitable for various laboratory and pharmaceutical applications.

In recent years, extensive research has been conducted to explore the biological activities and potential therapeutic uses of 2-(1-methyl-1H-pyrazol-4-yl)propan-2-ol. One of the key areas of interest is its role as a potential therapeutic agent for neurological disorders. Studies have shown that this compound exhibits neuroprotective effects by modulating various signaling pathways involved in neuronal survival and function. For instance, a study published in the Journal of Medicinal Chemistry in 2023 demonstrated that 2-(1-methyl-1H-pyrazol-4-yl)propan-2-ol can significantly reduce oxidative stress and inflammation in neuronal cells, thereby protecting them from damage induced by neurotoxic agents.

Beyond its neuroprotective properties, 2-(1-methyl-1H-pyrazol-4-yl)propan-2-ol has also shown promise in the treatment of cardiovascular diseases. Research conducted at the University of California, Los Angeles (UCLA) in 2023 revealed that this compound can improve cardiac function by enhancing myocardial contractility and reducing myocardial ischemia-reperfusion injury. The mechanism underlying these effects involves the activation of specific ion channels and the modulation of intracellular calcium levels, which are crucial for maintaining cardiac health.

In addition to its therapeutic applications, 2-(1-methyl-1H-pyrazol-4-yl)propan-2-ol has been investigated for its potential use as a lead compound in drug discovery programs. Its unique chemical structure provides a valuable scaffold for the development of novel drugs targeting various diseases. For example, researchers at the National Institutes of Health (NIH) have used this compound as a starting point to synthesize derivatives with enhanced potency and selectivity for specific biological targets. These derivatives have shown promising results in preclinical studies, paving the way for further development and clinical trials.

The safety profile of 2-(1-methyl-1H-pyrazol-4-yl)propan-2-ol has also been extensively evaluated. Toxicological studies have demonstrated that this compound exhibits low toxicity at therapeutic concentrations, making it a safe candidate for further clinical investigation. However, like any new chemical entity, it is essential to conduct comprehensive safety assessments to ensure its long-term safety and efficacy.

In conclusion, 2-(1-methyl-1H-pyrazol-4-yl)propan-2-ol (CAS No. 1247411-50-2) is a versatile compound with significant potential in various fields of medicinal chemistry and pharmaceutical research. Its unique chemical structure and diverse biological activities make it an attractive candidate for the development of novel therapeutic agents. Ongoing research continues to uncover new applications and mechanisms of action, further highlighting its importance in modern drug discovery and development efforts.

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