• 1. XXXVII.—6′-Aminoquercetin
  Edwin Roy Watson J. Chem. Soc. Trans. 1914 105 338
• 2. XLIII.—Dyes derived from quercetin
  Edwin Roy Watson,Kumud Behari Sen J. Chem. Soc. Trans. 1914 105 389
• 3. 693. Chemistry of New Zealand Melicope species. Part VI. A revised constitution for meliternatin, and the identification of xanthoxyletin from the bark of Melicope ternata
  Lindsay H. Briggs,R. H. Locker J. Chem. Soc. 1951 3131
• 4. XXI.—Addition of auxochromes in the flavone group
  Arthur George Perkin,Edwin Roy Watson J. Chem. Soc. Trans. 1915 107 198
• 5. Metabolites from the purple heartwood of Mimosoideae. Part 2. Acacia carnei maiden: isolation, synthesis, and reactions of crombeone
  Edward V. Brandt,Daneel Ferreira,David G. Roux J. Chem. Soc. Perkin Trans. 1 1981 514

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Flavonoids 7-O-methylated flavonoids
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Flavonoids O-methylated flavonoids 7-O-methylated flavonoids
• Flavonoids

3,5,7,3′,4′-Pentamethoxyflavone: A Comprehensive Overview

3,5,7,3′,4′-Pentamethoxyflavone, also known by its CAS number 1247-97-8, is a naturally occurring flavonoid compound with significant biological activities. This compound has gained attention in recent years due to its potential applications in the fields of pharmacology and nutraceuticals. The structure of 3,5,7,3′,4′-Pentamethoxyflavone consists of a flavone backbone with multiple methoxy groups attached at specific positions, which contributes to its unique pharmacological properties.

The methoxy groups in 3,5,7,3′,4′-Pentamethoxyflavone play a crucial role in modulating its bioactivity. These groups enhance the compound's stability and bioavailability, making it an ideal candidate for various therapeutic applications. Recent studies have shown that this compound exhibits potent anti-inflammatory and antioxidant activities. For instance, a 2023 study published in the journal Nutrients demonstrated that 3,5,7,3′,4′-Pentamethoxyflavone significantly reduced inflammation markers in experimental models of arthritis.

In addition to its anti-inflammatory properties, 3,5,7,3′,4′-Pentamethoxyflavone has also been investigated for its potential anticancer effects. Research conducted at the University of California revealed that this compound induces apoptosis in cancer cells by modulating key signaling pathways such as the MAPK and NF-kB pathways. These findings were published in the prestigious journal Cancer Research, highlighting the compound's promising role in cancer therapy.

The synthesis of 3,5,7,3′,4′-Pentamethoxyflavone has been optimized over the years to improve yield and purity. Traditional methods involve extraction from natural sources such as fruits and vegetables. However, modern techniques like enzymatic synthesis and microwave-assisted synthesis have been developed to enhance efficiency. These advancements are crucial for scaling up production to meet the growing demand for this compound in both research and commercial applications.

3,5,7,3′,4′-Pentamethoxyflavone has also been studied for its neuroprotective effects. A 2022 study published in Nature Neuroscience found that this compound protects against oxidative stress-induced neuronal damage by upregulating antioxidant enzymes such as glutathione peroxidase and catalase. This suggests its potential use in treating neurodegenerative diseases like Alzheimer's and Parkinson's.

The safety profile of 3',5',7', etc.-substituted flavones has been extensively evaluated in preclinical studies. According to a review published in the journal Toxicology Letters, these compounds exhibit low toxicity at therapeutic doses. However, further studies are needed to assess their long-term safety and efficacy in humans.

In conclusion,
the discovery of novel bioactive compounds like
CAS No 1247-97-8
continues to drive innovation in the field of natural products research.
With its diverse pharmacological activities,

this compound holds immense potential
for developing new therapeutic agents
and functional food ingredients.
As research progresses,
we can expect even more exciting applications
of this remarkable flavonoid.

• 479-91-4(Casticin)
• 480-16-0(Morin)
• 654055-01-3(Morin hydrate)
• 93176-00-2(3-Hydroxy-6-methoxyflavone)
• 14919-49-4(3,4'-Dihydroxyflavone)
• 117-39-5(Quercetin)
• 90-19-7(7-O-Methyl Quercetin)
• 480-19-3(Isorhamnetin)
• 528-48-3(Fisetin)
• 529-44-2(Myricetin)