Cas no 1246820-62-1 (Losartan-d)
Losartan-d is a deuterium-labeled analog of Losartan, a widely used angiotensin II receptor antagonist (ARB). The incorporation of deuterium atoms at specific positions enhances the metabolic stability of the molecule, making it particularly valuable for pharmacokinetic and pharmacodynamic studies. This isotopically labeled compound serves as an internal standard in mass spectrometry-based assays, ensuring high accuracy and reproducibility in quantitative analyses. Its structural similarity to Losartan allows for precise tracking of drug metabolism without interfering with biological activity. Losartan-d is essential in drug development research, offering improved reliability for tracing metabolic pathways and assessing drug-drug interactions. The deuterium labeling minimizes interference from endogenous compounds, facilitating clearer data interpretation in complex biological matrices.
Losartan-d structure
Product Name:Losartan-d
CAS No:1246820-62-1
MF:C22H21N6O2Cl
MW:436.89414
CID:1064143
PubChem ID:45359014
Update Time:2025-07-02
Losartan-d Chemical and Physical Properties
Names and Identifiers
-
- Losartan-d4 Carboxylic Acid
- 2-butyl-5-chloro-3-[[2,3,5,6-tetradeuterio-4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
- [2H4]-Losartan carboxylic acid
- 2-Butyl-4-chloro-1-[[2 inverted exclamation mark-(1H-tetrazol-5-yl)[1,1 inverted exclamation mark-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid-d4
- E-3174 D4
- EXP 3174-d4
- EXP-3174 D4
- Losartan (D4 Carboxylic Acid)
- Losartan D4 Carboxylic Acid
- Losartan-d
- E-3174;EXP-3174
- DA-75081
- 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid-d4; EXP 3174-d4;
- HY-12765S
- F85146
- ES-2608
- 2-Butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)(2,3,5,6-~2~H_4_)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylic acid
- Losartan Acid-D4
- DTXSID50670090
- 1ST40106
- WZB82062
- 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid-d4
- AKOS037652829
- AKOS040733614
- 1246820-62-1
-
- Inchi： InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)/i9D,10D,11D,12D
- InChI Key： ZEUXAIYYDDCIRX-IRYCTXJYSA-N
- SMILES： ClC1=C(C(O)=O)N(CC2=C([2H])C([2H])=C(C3=CC=CC=C3C4=NN=NN4)C([2H])=C2[2H])C(CCCC)=N1
Computed Properties
- Exact Mass: 440.16700
- Monoisotopic Mass: 440.1665586g/mol
- Isotope Atom Count: 4
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 31
- Rotatable Bond Count: 8
- Complexity: 590
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 5
- Topological Polar Surface Area: 110?2
Experimental Properties
- Melting Point: 105-110°C
- PSA: 109.58000
- LogP: 4.47270
Losartan-d Security Information
- Storage Condition：Please store the product under the recommended conditions in the Certificate of Analysis.
Losartan-d Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| MedChemExpress | HY-12765S-5mg |
Losartan-d |
1246820-62-1 | 98.17% | 5mg |
￥9800 | 2024-04-20 | |
| MedChemExpress | HY-12765S-10mg |
Losartan (D4 Carboxylic Acid) |
1246820-62-1 | 10mg |
￥15000 | 2021-07-09 | ||
| MedChemExpress | HY-12765S-1mg |
Losartan-d |
1246820-62-1 | 98.17% | 1mg |
￥2100 | 2024-04-20 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | L883672-1mg |
Losartan (D4 Carboxylic Acid) |
1246820-62-1 | 98% | 1mg |
￥2,736.00 | 2022-01-13 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | L883672-5mg |
Losartan (D4 Carboxylic Acid) |
1246820-62-1 | 98% | 5mg |
￥10,830.00 | 2022-01-13 | |
| ChemScence | CS-4056-5mg |
Losartan (D4 Carboxylic Acid) |
1246820-62-1 | 5mg |
$980.0 | 2022-04-28 | ||
| ChemScence | CS-4056-10mg |
Losartan (D4 Carboxylic Acid) |
1246820-62-1 | 10mg |
$1690.0 | 2022-04-28 | ||
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajce57204-1mg |
Losartan D4 Carboxylic Acid |
1246820-62-1 | 98% | 1mg |
￥2157.00 | 2023-09-07 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajce57204-5mg |
Losartan D4 Carboxylic Acid |
1246820-62-1 | 98% | 5mg |
￥8541.00 | 2023-09-07 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajce57204-10mg |
Losartan D4 Carboxylic Acid |
1246820-62-1 | 98% | 10mg |
￥15284.00 | 2023-09-07 |
Losartan-d Related Literature
-
J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
-
Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
-
Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
-
Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
1246820-62-1 (Losartan-d) Related Products
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