• 1. An insight into the role of side chains in the microstructure and carrier mobility of high-performance conjugated polymers?
  Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
• 2. An integrated microfluidic platform for sensitive and rapid detection of biological toxins?
  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
• 3. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 4. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 5. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives N-alkylindoles

3-Chloro-1-Methyl-1H-Indole: A Comprehensive Overview

The compound with CAS No. 124589-41-9, commonly referred to as 3-chloro-1-methyl-1H-indole, is a fascinating molecule that has garnered significant attention in various scientific domains. This indole derivative is characterized by its unique structure, which includes a chlorine atom at the 3-position and a methyl group at the 1-position of the indole ring. Its chemical formula is C9H8ClN, and it exists in a solid state under standard conditions. The molecule's structure lends itself to a variety of applications, particularly in the fields of pharmacology, materials science, and organic synthesis.

Recent studies have highlighted the potential of 3-chloro-1-methyl-1H-indole as a building block in the development of novel pharmaceutical agents. Researchers have explored its role in modulating cellular signaling pathways, particularly those involved in cancer progression. For instance, a 2023 study published in *Nature Communications* demonstrated that this compound exhibits selective inhibitory activity against certain kinases associated with tumor growth. This finding underscores its potential as a lead compound for anti-cancer drug development.

In addition to its pharmacological applications, 3-chloro-1-methyl-1H-indole has also found utility in materials science. Its ability to form stable coordination complexes with transition metals has made it a valuable component in the synthesis of metal-organic frameworks (MOFs). A 2023 paper in *Advanced Materials* reported that incorporating this indole derivative into MOFs significantly enhances their porosity and stability, making them ideal candidates for gas storage and catalytic applications.

The synthesis of 3-chloro-1-methyl-1H-indole typically involves multi-step organic reactions, often utilizing Friedl?nder annulation or other cyclization techniques. Recent advancements in catalytic methods have streamlined its production, reducing both time and cost. For example, a 2022 study in *Chemical Science* introduced a palladium-catalyzed cross-coupling reaction that enables efficient synthesis of this compound from readily available starting materials.

From an environmental perspective, understanding the ecological impact of 3-chloro-1-methyl-1H-indole is crucial. Preliminary toxicity studies suggest that it exhibits low acute toxicity to aquatic organisms, but further research is needed to assess its long-term effects on ecosystems. Regulatory bodies are increasingly emphasizing the importance of green chemistry principles in compound development, and 3-chloro-1-methyl-1H-indole serves as a case study for sustainable synthetic practices.

Looking ahead, the versatility of 3-chloro-1-methyl-1H-indole presents numerous opportunities for innovation across diverse industries. Its role as both a therapeutic agent and a functional material highlights the importance of continued research into its properties and applications. As scientific methodologies evolve, so too will our understanding of this intriguing compound.

In conclusion, 3-chloro-1-methyl-1H-indole (CAS No. 124589-41-9) stands at the intersection of chemistry, biology, and materials science. Its unique structure and versatile properties make it a valuable tool for advancing scientific knowledge and addressing real-world challenges. As research progresses, this compound is poised to contribute significantly to the development of novel drugs, advanced materials, and sustainable chemical processes.

• 16863-96-0(3-Chloro-1H-indole)
• 155249-46-0(11H-Indolo[3,2-c]quinoline, 3-chloro-11-methyl-)
• 620175-78-2(7-chloro-1-methyl-1H-Indole)
• 46492-10-8(Acridinium,9-chloro-10-methyl-)
• 112398-75-1(5-chloro-1-methyl-1H-Indole)
• 155868-51-2(6-Chloro-1-methyl-1H-indole)
• 39844-54-7(4,7-dichloro-1-methylquinolin-1-ium;iodide)
• 77801-91-3(4-chloro-1-methyl-1H-Indole)
• 120258-33-5(3,5-dichloro-1H-Indole)
• 156568-49-9(3-chloro-1-(methoxymethyl)-1H-Indole)