Cas no 124499-20-3 (tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate)

Technical Introduction: Tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate is a versatile intermediate in organic synthesis, particularly valued for its bifunctional structure combining a protected carboxylate (tert-butyl ester) and a primary amine group. The tert-butyl ester moiety enhances stability under basic conditions, while the aminoethyl group facilitates further derivatization, making it useful in peptide coupling, pharmaceutical synthesis, and material science applications. Its aromatic core contributes to rigidity, aiding in the design of structured compounds. The compound’s balanced reactivity and protective group strategy make it a practical choice for multistep syntheses requiring selective deprotection or functionalization. Storage under inert conditions is recommended to preserve amine integrity.
tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate structure
124499-20-3 structure
Product Name:tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate
CAS No:124499-20-3
MF:C14H21NO2
MW:235.32204413414
MDL:MFCD04114528
CID:105311
PubChem ID:14775459
Update Time:2025-05-19

tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate Chemical and Physical Properties

Names and Identifiers

    • tert-Butyl 2-(4-(2-aminoethyl)phenyl)acetate
    • Benzeneacetic acid,4-(2-aminoethyl)-, 1,1-dimethylethyl ester
    • TERT-BUTYL [4-(2-AMINO-ETHYL)-PHENYL]-ACETATE
    • tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate
    • t-Butyl 4-(2-aMinoethyl)phenylacetate
    • CS-0272771
    • tert-Butyl[4-(2-amino-ethyl)-phenyl]-acetate
    • AKOS015999781
    • [4-(2-amino-ethyl)phenyl]-acetic acid t-butyl ester
    • F2147-2852
    • tert-Butyl [4-(2-amino-ethyl)-phenyl]-acetate, AldrichCPR
    • CMJIKWRJLCDJQU-UHFFFAOYSA-N
    • MFCD04114528
    • Benzeneacetic acid, 4-(2-aminoethyl)-, 1,1-dimethylethyl ester
    • tert-Butyl [4-(2-amino-ethyl)phenyl]acetate
    • DTXSID80563906
    • A805240
    • SCHEMBL1732992
    • tert-Butyl [4-(2-aminoethyl)phenyl]acetate
    • 124499-20-3
    • AB18516
    • EN300-1265140
    • CCG-358840
    • [4-(2-amino-ethyl) phenyl]-acetic acid t-butyl ester
    • G85006
    • MDL： MFCD04114528
    • Inchi： 1S/C14H21NO2/c1-14(2,3)17-13(16)10-12-6-4-11(5-7-12)8-9-15/h4-7H,8-10,15H2,1-3H3
    • InChI Key： CMJIKWRJLCDJQU-UHFFFAOYSA-N
    • SMILES： O(C(CC1C=CC(=CC=1)CCN)=O)C(C)(C)C

Computed Properties

  • Exact Mass: 235.15700
  • Monoisotopic Mass: 235.157228913g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 17
  • Rotatable Bond Count: 6
  • Complexity: 237
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2
  • Topological Polar Surface Area: 52.3?2

Experimental Properties

  • PSA: 52.32000
  • LogP: 2.77230

tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate Customs Data

  • HS CODE：2922499990
  • Customs Data：

    China Customs Code:

    2922499990

    Overview:

    2922499990 Other amino acids and their esters and their salts(Except those containing more than one oxygen-containing group). VAT:17.0% Tax refund rate:9.0% Regulatory conditions:AB(Customs clearance form for Inbound Goods,Customs clearance form for outbound goods) MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Regulatory conditions:

    A.Customs clearance form for Inbound Goods
    B.Customs clearance form for outbound goods

    Inspection and quarantine category:

    P.Imported animals and plants\Quarantine of animal and plant products
    Q.Outbound animals and plants\Quarantine of animal and plant products
    R.Sanitary supervision and inspection of imported food
    S.Sanitary supervision and inspection of exported food
    M.Import commodity inspection
    N.Export commodity inspection

    Summary:

    HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate Pricemore >>

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tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate Related Literature

Related Categories

Additional information on tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate

Comprehensive Overview of tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate (CAS No. 124499-20-3): Properties, Applications, and Industry Insights

tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate (CAS No. 124499-20-3) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural features and versatile applications. This ester derivative, characterized by its tert-butyl group and aminoethyl functionality, serves as a critical intermediate in the synthesis of bioactive molecules. Its molecular formula, C14H21NO2, reflects a balanced hydrophobicity and reactivity, making it valuable for drug discovery and material science.

In recent years, the demand for tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate has surged, driven by its role in developing small-molecule therapeutics and peptide mimetics. Researchers frequently explore its potential in central nervous system (CNS) drug design, leveraging the aminoethyl moiety for receptor targeting. The compound’s CAS No. 124499-20-3 is often cited in patents related to neurodegenerative disease treatments, aligning with global trends in aging populations and brain health awareness.

The synthesis of tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate typically involves multi-step organic reactions, including esterification and reductive amination. Its tert-butyl group enhances stability during storage and handling, while the phenylacetate backbone allows for further functionalization. These attributes make it a preferred choice for high-throughput screening libraries and combinatorial chemistry, addressing the pharmaceutical industry’s need for scalable intermediates.

From an environmental and regulatory perspective, tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate is classified as a non-hazardous substance under standard conditions, though proper laboratory practices are recommended. Its low ecotoxicity profile aligns with the growing emphasis on green chemistry and sustainable synthesis—topics frequently searched in academic and industrial forums. This positions the compound favorably for FDA-approved drug pipelines and bioconjugation applications.

Market analyses indicate that CAS No. 124499-20-3 is increasingly procured by contract research organizations (CROs) and generic drug manufacturers. The rise of personalized medicine and orphan drug development has further amplified its relevance. Additionally, its utility in proteomics research and fluorescent labeling techniques underscores its cross-disciplinary appeal.

In conclusion, tert-butyl 2-[4-(2-aminoethyl)phenyl]acetate exemplifies the intersection of innovation and practicality in modern chemistry. Its structural adaptability, coupled with expanding applications in life sciences and material engineering, ensures its continued prominence. As research into targeted drug delivery and biocompatible materials advances, this compound is poised to remain a cornerstone of cutting-edge scientific endeavors.

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