Cas no 124467-23-8 (2-chloro-8-fluoro-quinoline)

2-Chloro-8-fluoro-quinoline is a fluorinated and chlorinated quinoline derivative with significant utility in pharmaceutical and agrochemical research. The presence of both chloro and fluoro substituents enhances its reactivity, making it a versatile intermediate for synthesizing complex heterocyclic compounds. Its electron-withdrawing properties facilitate nucleophilic substitution reactions, enabling precise modifications for targeted applications. The compound's stability under various reaction conditions and its compatibility with cross-coupling methodologies further underscore its value in medicinal chemistry and material science. Researchers favor this scaffold for its potential in developing bioactive molecules, including kinase inhibitors and antimicrobial agents. Its well-defined structure ensures reproducibility in synthetic pathways.
2-chloro-8-fluoro-quinoline structure
2-chloro-8-fluoro-quinoline structure
Product Name:2-chloro-8-fluoro-quinoline
CAS No:124467-23-8
MF:C9H5ClFN
MW:181.594104528427
MDL:MFCD16140178
CID:1025161
PubChem ID:22125194
Update Time:2025-05-19

2-chloro-8-fluoro-quinoline Chemical and Physical Properties

Names and Identifiers

    • 2-Chloro-8-fluoroquinoline
    • Quinoline,2-chloro-8-fluoro
    • 2-chloro-8-fluoro-quinoline
    • Quinoline, 2-chloro-8-fluoro-
    • 124467-23-8
    • AKOS005258119
    • ZEA46723
    • STL555202
    • CS-0442996
    • SY259349
    • 2-Chloro-8-fluoroquinoline, 95%
    • BBL101406
    • MFCD16140178
    • AS-39267
    • DB-355947
    • DTXSID40622629
    • CSPMWYOOKWBXRI-UHFFFAOYSA-N
    • F6437-0230
    • SB67633
    • EN300-1197933
    • SCHEMBL1967396
    • AU-004/43508257
    • MDL： MFCD16140178
    • Inchi： 1S/C9H5ClFN/c10-8-5-4-6-2-1-3-7(11)9(6)12-8/h1-5H
    • InChI Key： CSPMWYOOKWBXRI-UHFFFAOYSA-N
    • SMILES： ClC1=CC=C2C=CC=C(C2=N1)F

Computed Properties

  • Exact Mass: 181.00900
  • Monoisotopic Mass: 181.0094550g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 0
  • Complexity: 165
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.3
  • Topological Polar Surface Area: 12.9?2

Experimental Properties

  • Melting Point: 75-85?°C
  • PSA: 12.89000
  • LogP: 3.02730

2-chloro-8-fluoro-quinoline Security Information

  • Symbol: GHS05 GHS07
  • Signal Word：Danger
  • Hazard Statement： H302-H318
  • Warning Statement： P280-P305+P351+P338
  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：3
  • Hazard Category Code： 22-41
  • Safety Instruction： 26-39
  • Hazardous Material Identification： Xn
  • HazardClass：IRRITANT

2-chloro-8-fluoro-quinoline Customs Data

  • HS CODE：2933499090
  • Customs Data：

    China Customs Code:

    2933499090

    Overview:

    2933499090. Other compounds containing quinoline or isoquinoline ring system [but not further fused]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-chloro-8-fluoro-quinoline Pricemore >>

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2-chloro-8-fluoro-quinoline Production Method

2-chloro-8-fluoro-quinoline Related Literature

Additional information on 2-chloro-8-fluoro-quinoline

Comprehensive Overview of 2-Chloro-8-Fluoro-Quinoline (CAS No. 124467-23-8): Properties, Applications, and Industry Trends

2-Chloro-8-fluoro-quinoline (CAS No. 124467-23-8) is a halogenated quinoline derivative that has garnered significant attention in pharmaceutical and agrochemical research due to its versatile structural framework. The compound's unique chloro-fluoro substitution pattern enhances its reactivity, making it a valuable intermediate in synthetic chemistry. This article delves into its molecular characteristics, industrial applications, and emerging trends, addressing common queries such as "2-chloro-8-fluoro-quinoline synthesis" and "CAS 124467-23-8 uses," which are frequently searched in academic and commercial databases.

The quinoline core of this compound is a privileged scaffold in drug discovery, often associated with antimicrobial, anticancer, and anti-inflammatory properties. Researchers have explored 2-chloro-8-fluoro-quinoline as a precursor for designing kinase inhibitors and fluorescence probes, aligning with the growing demand for targeted therapies and diagnostic tools. Its electron-withdrawing substituents (chloro and fluoro groups) improve binding affinity to biological targets, a feature highlighted in recent publications on structure-activity relationships (SAR).

From an industrial perspective, CAS 124467-23-8 is utilized in the production of advanced materials, including organic light-emitting diodes (OLEDs) and liquid crystal displays (LCDs). The compound's photophysical properties are leveraged to enhance device efficiency, a topic trending in "green chemistry innovations" discussions. Additionally, its role in catalyic cross-coupling reactions (e.g., Suzuki-Miyaura couplings) addresses the need for sustainable synthetic methodologies, a focal point in 2024 chemical research priorities.

Environmental and regulatory considerations are also critical. While 2-chloro-8-fluoro-quinoline is not classified as hazardous under major regulatory frameworks, its handling requires adherence to Good Laboratory Practices (GLP). Searches like "124467-23-8 safety data" reflect user concerns about workplace safety, prompting manufacturers to provide detailed material safety data sheets (MSDS) and life cycle assessment (LCA) reports.

In conclusion, 2-chloro-8-fluoro-quinoline exemplifies the intersection of medicinal chemistry and materials science. Its adaptability to high-throughput screening and green synthesis positions it as a compound of enduring relevance. For researchers querying "quinoline derivatives 2024" or "halogenated heterocycles suppliers," this compound offers a compelling case study in innovation-driven applications.

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