• 1. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 2. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 3. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
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• 4. An amorphous lanthanum–iridium solid solution with an open structure for efficient water splitting?
  Wei Sun,Chenglong Ma,Xinlong Tian,Jianjun Liao,Ji Yang,Chengjun Ge,Weiwei Huang J. Mater. Chem. A, 2020,8, 12518-12525
• 5. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126

Comprehensive Overview of 1-(2,6-Dichlorophenyl)-1H-pyrazole (CAS No. 1242336-72-6): Properties, Applications, and Industry Insights

1-(2,6-Dichlorophenyl)-1H-pyrazole (CAS No. 1242336-72-6) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural framework. The molecule features a pyrazole ring bonded to a 2,6-dichlorophenyl group, a configuration known for enhancing bioactivity and stability. This article delves into its chemical properties, synthetic pathways, and emerging applications, while addressing trending queries like "pyrazole derivatives in drug discovery" and "chlorinated phenyl compounds in crop protection."

The molecular formula C₉H₆Cl₂N₂ and molecular weight of 213.06 g/mol underscore its compact yet potent nature. Researchers highlight its role as a key intermediate in synthesizing biologically active molecules, particularly those targeting enzyme inhibition or receptor modulation. Recent studies explore its potential in anti-inflammatory agents and antifungal formulations, aligning with the growing demand for sustainable agrochemicals and precision medicine solutions.

From a synthesis perspective, 1-(2,6-Dichlorophenyl)-1H-pyrazole is typically prepared via cyclocondensation reactions between hydrazines and 1,3-diketones, followed by selective chlorination. Innovations in green chemistry have introduced catalytic methods to reduce waste, resonating with the industry's shift toward eco-friendly synthesis. Analytical techniques like HPLC and NMR spectroscopy are critical for purity assessment, ensuring compliance with Good Manufacturing Practices (GMP).

The compound's structure-activity relationship (SAR) has been a focal point in medicinal chemistry. Its dichlorophenyl moiety enhances lipophilicity, improving membrane permeability—a trait exploited in CNS drug development. Concurrently, the pyrazole core offers hydrogen-bonding sites, enabling interactions with biological targets. These attributes have spurred investigations into its utility for neurodegenerative disease therapeutics, a hot topic in biopharmaceutical forums.

In agrochemicals, 1-(2,6-Dichlorophenyl)-1H-pyrazole derivatives are explored as next-generation pesticides with lower environmental persistence. Searches for "chlorophenyl pyrazole insecticide alternatives" reflect regulatory pressures to phase out traditional organophosphates. Its mode of action, often involving mitochondrial disruption in pests, positions it as a candidate for integrated pest management (IPM) systems.

Market analysts note rising patent filings related to this compound, particularly in Asia-Pacific and North America, driven by R&D investments in crop enhancement and orphan drug development. Regulatory frameworks like REACH and FDA guidelines necessitate rigorous toxicological profiling, with recent data suggesting favorable ecotoxicology parameters for scaled applications.

Future directions include nanocarrier formulations to enhance bioavailability and computational modeling to predict novel derivatives. As industries prioritize carbon-neutral synthesis, 1-(2,6-Dichlorophenyl)-1H-pyrazole exemplifies how tailored heterocycles can address global challenges in health and agriculture while adhering to ESG (Environmental, Social, Governance) principles.

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