Cas no 124151-33-3 ((E)-Coniferin)

(E)-Coniferin is a naturally occurring phenylpropanoid glycoside, primarily found in coniferous plants. It serves as a key intermediate in lignin biosynthesis and is widely utilized in biochemical and phytochemical research. The compound is valued for its role in studying plant cell wall formation and enzymatic processes involving β-glucosidases. (E)-Coniferin is characterized by its high purity and stability, making it suitable for analytical standards and metabolic pathway investigations. Its structural specificity allows for precise research applications in plant physiology and lignin-related studies. The product is typically supplied as a white crystalline powder, ensuring consistent performance in laboratory settings.
(E)-Coniferin structure
(E)-Coniferin structure
Product Name:(E)-Coniferin
CAS No:124151-33-3
MF:C16H22O8
MW:342.341085910797
CID:2077642
PubChem ID:5280372
Update Time:2025-05-23

(E)-Coniferin Chemical and Physical Properties

Names and Identifiers

    • 3'-Me ether,4'-O-beta-D-glucopyranoside-(E)-3-(3,4-Dihydroxyphenyl)-2-propen-1-ol
    • 4-(3-hydroxy-1-propenyl)-2-methoxyphenyl-beta-D-glucopyranoside
    • 4-(3-hydroxyprop-1-en-1-yl)-2-methoxyphenyl beta-D-glucopyranoside
    • 4-[(1E)-3-hydroxyprop-1-enyl]-2-methoxyphenyl beta-D-glucopyranoside
    • 4-hydroxy-3-methoxycinnamyl alcohol-4-O-beta-D-glucopyranoside
    • abietin
    • coniferin
    • coniferoside
    • Coniferyl alcohol 4-O-glucoside
    • trans-Coniferin
    • (E)-Coniferin
    • (E)-3-[3-Methoxy-4-(β-D-glucopyranosyloxy)phenyl]-2-propene-1-ol
    • 4-[(E)-3-Hydroxy-1-propenyl]-2-methoxyphenyl β-D-glucopyranoside
    • 2-Methoxy-4-[(E)-3-hydroxy-1-propenyl]phenyl β-D-glucopyranoside
    • [4-[(E)-3-Hydroxy-1-propenyl]-2-methoxyphenyl]β-D-glucopyranoside
    • (E)-Laricin
    • CONIFERYL ALCOHOL .BETA.-D-GLUCOSIDE
    • (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{4-[(1E)-3-hydroxyprop-1-en-1-yl]-2-methoxyphenoxy}oxane-3,4,5-triol
    • Coniferyl alcohol I2-glucoside
    • 4-Hydroxy-3-methoxy-1-(I3-hydroxypropenyl)benzene-4-D-glucoside
    • (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(4-((E)-3-hydroxyprop-1-en-1-yl)-2-methoxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol
    • 4-O-(b-D-Glucosyl)-trans-coniferol
    • bmse000608
    • 2-(hydroxymethyl)-6-(4-(3-hydroxyprop-1-enyl)-2-methoxyphenoxy)oxane-3,4,5-triol
    • 4-((1E)-3-Hydroxy-1-propen-1-yl)-2-methoxyphenyl I2-D-glucopyranoside
    • HY-N3617
    • CHEBI:16220
    • MLS000563468
    • CONIFERIN [MI]
    • Coniferyl alcohol b-D-glucoside
    • SCHEMBL321115
    • Coniferyl alcohol I2-D-glucoside
    • MEGxp0_000873
    • BDBM50269612
    • MS-25232
    • Coniferyl alcohol beta-glucoside
    • Coniferyl alcohol beta-D-glucoside
    • C16H22O8
    • NS00097552
    • HMS2267N17
    • AKOS032948392
    • NCGC00179896-02
    • DA-50091
    • Laricin
    • 3-(4beta-D-Glucopyranosyloxy-3-methoxy)phenyl-(2E)-propenol
    • 531-29-3
    • 4-hydroxy-3-methoxy-1-(gamma-hydroxypropenyl)benzene-4-D-glucoside
    • 124151-33-3
    • NCGC00179896-01
    • 3-(4-beta-D-Glucopyranosyloxy-3-methoxyphenyl)-2-propen-1-ol
    • (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-[(E)-3-hydroxyprop-1-enyl]-2-methoxyphenoxy]oxane-3,4,5-triol
    • Coniferosid
    • SMR000470885
    • E80725
    • BRD-K70130576-001-01-7
    • 4-[(1E)-3-Hydroxy-1-propen-1-yl]-2-methoxyphenyl beta-D-glucopyranoside
    • CHEMBL459056
    • (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-((1E)-3-hydroxyprop-1-en-1-yl)-2-methoxyphenoxy)oxane-3,4,5-triol
    • beta-D-Glucopyranoside, 4-(3-hydroxy-1-propenyl)-2-methoxyphenyl
    • 4-(3-Hydroxyprop-1-en-1-yl)-2-methoxyphenyl beta-delta-glucopyranoside
    • 4-(3-Hydroxy-1-propen-1-yl)-2-methoxyphenyl beta-glucopyranoside
    • C00761
    • 4-(3-Hydroxy-1-propen-1-yl)-2-methoxyphenyl I2-glucopyranoside
    • 4-O-(beta-D-glucosyl)-trans-coniferol
    • ACon1_002032
    • CS-0023945
    • 2-(hydroxymethyl)-6-[4-(3-hydroxyprop-1-enyl)-2-methoxyphenoxy]oxane-3,4,5-triol
    • 4-(3-Hydroxy-1-propenyl)-2-methoxyphenyl-I2-D-glucopyranoside
    • beta-D-Glucopyranoside, 4-(3-hydroxy-1-propenyl)-2-methoxyphenyl (VAN)
    • Q358968
    • coniferyl alcohol-4-O-beta-D-glucopyranoside
    • DA-48744
    • 4-((1E)-3-Hydroxy-1-propen-1-yl)-2-methoxyphenyl beta-D-glucopyranoside
    • 4-[(1E)-3-Hydroxy-1-propen-1-yl]-2-methoxyphenyl I2-D-glucopyranoside
    • UNII-M6616XLU2J
    • 3-(4beta-D-Glucopyranosyloxy-3-methoxy)phenyl-2E-propenol
    • M6616XLU2J
    • Coniferyl alcohol beta-delta-glucoside
    • (2R,3S,4S,5R,6S)-2-(HYDROXYMETHYL)-6-(4-((E)-3-HYDROXYPROP-1-ENYL)-2-METHOXYPHENOXY)OXANE-3,4,5-TRIOL
    • MC16663
    • 4-(3-Hydroxy-1-propen-1-yl)-2-methoxyphenyl b-glucopyranoside;4-Hydroxy-3-methoxy-1-(gamma-hydroxypropenyl)benzene-4-D-glucoside;Abi etin
    • Inchi： 1S/C16H22O8/c1-22-11-7-9(3-2-6-17)4-5-10(11)23-16-15(21)14(20)13(19)12(8-18)24-16/h2-5,7,12-21H,6,8H2,1H3/b3-2+/t12-,13-,14+,15-,16-/m1/s1
    • InChI Key： SFLMUHDGSQZDOW-FAOXUISGSA-N
    • SMILES： O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O)OC1C=CC(/C=C/CO)=CC=1OC

Computed Properties

  • Exact Mass: 342.13146766g/mol
  • Monoisotopic Mass: 342.13146766g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 5
  • Hydrogen Bond Acceptor Count: 8
  • Heavy Atom Count: 24
  • Rotatable Bond Count: 6
  • Complexity: 404
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 5
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -1.3
  • Topological Polar Surface Area: 129?2

Experimental Properties

  • Density: 1.432±0.06 g/cm3 (20 oC 760 Torr),
  • Solubility: Slightly soluble (13 g/l) (25 o C),

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(E)-Coniferin Suppliers

Amadis Chemical Company Limited
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(CAS:124151-33-3)(E)-Coniferin
Order Number:A1010661
Stock Status:in Stock
Quantity:10mg/20mg
Purity:99%
Pricing Information Last Updated:Thursday, 29 August 2024 15:10
Price ($):329.0/226.0

(E)-Coniferin Related Literature

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Additional information on (E)-Coniferin

(E)-Coniferin (CAS No. 124151-33-3): A Comprehensive Overview in Modern Chemical and Pharmaceutical Research

(E)-Coniferin, identified by its Chemical Abstracts Service (CAS) number 124151-33-3, is a naturally occurring flavonoid glycoside that has garnered significant attention in the fields of chemical biology and pharmaceutical research. This compound, derived from coniferin, exhibits a unique structural configuration that distinguishes it from other flavonoid derivatives. Its molecular formula and stereochemistry contribute to its distinct pharmacological properties, making it a subject of extensive study for potential therapeutic applications.

The structural elucidation of (E)-Coniferin has been a cornerstone in understanding its biological activity. Flavonoids, known for their diverse pharmacological effects, are widely studied for their antioxidant, anti-inflammatory, and antimicrobial properties. (E)-Coniferin, with its chiral center and conjugated system, demonstrates enhanced stability and bioavailability compared to its isomers. This structural feature has prompted researchers to explore its potential in drug development, particularly in the context of chronic diseases where oxidative stress and inflammation play pivotal roles.

Recent advancements in metabolomics and phytochemistry have highlighted the significance of (E)-Coniferin in natural product research. Studies indicate that this compound is abundantly found in certain plant species, particularly those belonging to the Pinaceae family. The extraction and purification processes of (E)-Coniferin have been refined to ensure high yield and purity, making it more accessible for clinical trials and industrial applications.

The pharmacological profile of (E)-Coniferin has been extensively evaluated in vitro and in vivo. Research has demonstrated its potential role in modulating enzyme activities associated with metabolic pathways relevant to neurodegenerative diseases. Specifically, studies have shown that (E)-Coniferin can inhibit the aggregation of amyloid-beta peptides, a hallmark of Alzheimer's disease, thereby offering a promising therapeutic strategy against this debilitating condition.

Moreover, the anti-inflammatory properties of (E)-Coniferin have been explored in models of rheumatoid arthritis. By modulating cytokine production and inhibiting pro-inflammatory enzymes such as COX-2 and LOX, (E)-Coniferin has shown significant promise in reducing inflammation and pain associated with arthritis. These findings align with the growing interest in natural compounds as alternatives or adjuvants to conventional pharmaceuticals.

The role of (E)-Coniferin in cardiovascular health is another area of active research. Studies have indicated that this flavonoid glycoside can improve endothelial function by enhancing nitric oxide production and reducing oxidative stress. This effect is particularly relevant in the context of atherosclerosis, where endothelial dysfunction is a key pathological feature. The ability of (E)-Coniferin to modulate lipid profiles further underscores its potential as a cardioprotective agent.

In oncology research, (E)-Coniferin has been investigated for its chemopreventive properties. Preclinical studies suggest that this compound can induce apoptosis in cancer cells while sparing healthy cells. Its mechanism involves the activation of intrinsic apoptotic pathways and the inhibition of survival signaling cascades such as Akt and MAPK. These findings position (E)-Coniferin as a candidate for further development into chemotherapeutic agents or chemopreventive supplements.

The bioavailability of (E)-Coniferin has been a focus of pharmacokinetic studies. Research indicates that when administered orally, this compound undergoes extensive metabolism but still retains significant bioactivity due to its stable conjugated system. The identification of metabolic pathways has allowed researchers to optimize delivery systems, such as nanoformulations or prodrugs, to enhance absorption and efficacy.

The synthesis of (E)-Coniferin has also been an area of interest for synthetic chemists aiming to develop scalable production methods. Advances in enzymatic synthesis have enabled the efficient production of this compound without compromising its stereochemical integrity. This development is crucial for ensuring a sustainable supply chain for both research purposes and potential commercialization.

The regulatory landscape surrounding the use of (E)-Coniferin is evolving as more data becomes available on its safety and efficacy. Regulatory bodies are increasingly recognizing natural products like flavonoids as valuable therapeutic agents, provided they meet stringent quality control standards. The growing body of evidence supporting the benefits of (E)-Coniferin may lead to its inclusion in future pharmacopeias or approval for specific therapeutic indications.

Future directions in research on (E)-Coniferin include exploring its potential synergies with other bioactive compounds found in natural extracts. Combination therapies may enhance therapeutic outcomes by targeting multiple disease pathways simultaneously. Additionally, investigating the long-term effects and dosing regimens will be crucial for translating preclinical findings into clinical practice.

In conclusion,(E)-Coniferin (CAS No. 124151-33-3) represents a promising natural product with diverse pharmacological applications ranging from neuroprotection to cancer therapy. Its unique structural features contribute to its biological activity, while ongoing research continues to uncover new therapeutic potentials. As our understanding of this compound evolves, so too will its role in modern medicine.

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Amadis Chemical Company Limited
(CAS:124151-33-3)(E)-Coniferin
A1010661
Purity:99%/99%
Quantity:10mg/20mg
Price ($):329.0/226.0
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