• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 3. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 4. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
  Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197
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  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aniline and substituted anilines

4-Ethynyl-3,5-Difluoro-Aniline: A Comprehensive Overview

4-Ethynyl-3,5-Difluoro-Aniline, identified by the CAS Registry Number 1233501-56-8, is a versatile aromatic compound with significant applications in organic synthesis and materials science. This compound is characterized by its unique structure, which combines an aniline backbone with ethynyl and difluoro substituents. The presence of the triple bond in the ethynyl group introduces reactivity that makes this compound valuable in various chemical transformations.

The synthesis of 4-Ethynyl-3,5-Difluoro-Aniline typically involves multi-step processes, often starting from fluorinated aniline derivatives. Recent advancements in catalytic methods have enabled more efficient syntheses, reducing reaction times and improving yields. For instance, the use of palladium-catalyzed cross-coupling reactions has been pivotal in constructing the ethynyl group with high precision.

In terms of applications, 4-Ethynyl-3,5-Difluoro-Aniline has shown promise in the development of advanced materials. Its ability to undergo click chemistry reactions makes it a valuable precursor for functional polymers and nanoparticles. Researchers have explored its use in creating stimuli-responsive materials, which can change properties under specific conditions such as temperature or pH changes.

The electronic properties of 4-Ethynyl-3,5-Difluoro-Aniline are also of interest in the field of optoelectronics. The fluorine substituents enhance the molecule's electron-withdrawing effects, which can be leveraged in designing organic light-emitting diodes (OLEDs) and photovoltaic devices. Recent studies have demonstrated improved device performance when this compound is incorporated into conjugated systems.

Beyond materials science, 4-Ethynyl-3,5-Difluoro-Aniline has potential applications in drug discovery. Its structure allows for modulation of pharmacokinetic properties, making it a candidate for bioisosteric replacements in medicinal chemistry. The compound's reactivity also facilitates the construction of complex molecular frameworks required for novel therapeutic agents.

In conclusion, 4-Ethynyl-3,5-Difluoro-Aniline, with its unique structural features and versatile reactivity, continues to be a focal point in chemical research. Its applications span across multiple disciplines, driven by ongoing innovations in synthetic methodologies and material design.

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• 61794-59-0(4-ethynyl-2,3,5,6-tetrafluoroaniline)
• 656798-47-9(Benzenamine, 4-[(pentafluorophenyl)ethynyl]-)
• 452-77-7(3-Fluoro-4-methylaniline)
• 653563-92-9(Benzenamine, 4-[[4-[(pentafluorophenyl)ethynyl]phenyl]ethynyl]-)
• 1792939-17-3(3-Ethynyl-2,4-difluoroaniline)
• 878285-13-3(3,5-Difluoro-4-methylaniline)
• 1233501-57-9(4-ethynyl-3-fluoro-aniline)