• 1. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 2. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 4. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 5. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aniline and substituted anilines

Research Brief on 3-Chloro-5-ethylaniline (CAS: 123158-74-7) in Chemical and Biomedical Applications

3-Chloro-5-ethylaniline (CAS: 123158-74-7) is a halogenated aniline derivative that has garnered significant attention in recent years due to its versatile applications in pharmaceutical synthesis, agrochemical development, and material science. This research brief consolidates the latest findings on this compound, focusing on its synthetic pathways, biological activities, and potential industrial uses. The compound's unique structural features, including the chloro and ethyl substituents on the aromatic ring, contribute to its reactivity and functional diversity, making it a valuable intermediate in organic synthesis.

Recent studies have highlighted the role of 3-Chloro-5-ethylaniline in the development of novel pharmacophores. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility as a precursor in the synthesis of kinase inhibitors, particularly targeting tyrosine kinases involved in cancer progression. The compound's ability to undergo selective functionalization at the amino group and the aromatic ring positions it as a key building block for structure-activity relationship (SAR) studies. Computational modeling further supports its potential in drug design, with docking studies revealing favorable interactions with various enzyme active sites.

In agrochemical research, 3-Chloro-5-ethylaniline has been investigated as a scaffold for developing next-generation herbicides and fungicides. A patent filed in 2024 by a leading agrochemical company describes its incorporation into novel sulfonylurea derivatives, exhibiting enhanced herbicidal activity against resistant weed species. The compound's stability under environmental conditions and its metabolic profile in plants have been characterized, providing insights into its mode of action and environmental fate. These findings underscore its potential to address challenges in sustainable agriculture.

The synthetic accessibility of 3-Chloro-5-ethylaniline has also been a focus of recent optimization efforts. A 2023 Organic Process Research & Development article detailed a scalable, green chemistry approach to its production, utilizing catalytic C-H activation and minimizing hazardous byproducts. This advancement addresses previous limitations in large-scale manufacturing, paving the way for broader industrial adoption. Furthermore, spectroscopic characterization (including NMR and mass spectrometry) of the compound and its derivatives has been refined, enabling more accurate quality control in production settings.

Emerging applications in material science have expanded the compound's utility beyond traditional chemical domains. Researchers have recently explored its incorporation into conductive polymers and metal-organic frameworks (MOFs), where its electron-donating properties and structural rigidity contribute to enhanced material performance. These developments position 3-Chloro-5-ethylaniline as a multifunctional chemical entity with cross-disciplinary relevance. Future research directions may focus on exploring its enantioselective transformations and investigating its biological profile in greater depth to unlock additional therapeutic potentials.

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