• 1. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 2. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 3. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 4. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
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• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

1-(2,3-Difluorophenyl)ethanol: A Versatile Compound in Pharmaceutical and Chemical Research

1-(2,3-Difluorophenyl)ethanol (CAS No. 1228690-56-9) is a fluorinated aromatic alcohol that has garnered significant attention in recent years due to its unique chemical properties and potential applications in pharmaceutical and chemical research. This compound is characterized by its 2,3-difluorophenyl substituent, which imparts distinct electronic and steric effects, making it a valuable building block in the synthesis of various bioactive molecules.

The synthesis of 1-(2,3-Difluorophenyl)ethanol can be achieved through several methods, including the reduction of 1-(2,3-difluorophenyl)ethanone or the hydrolysis of 1-(2,3-difluorophenyl)ethyl chloride. These synthetic routes have been extensively studied and optimized to ensure high yields and purity. Recent advancements in catalytic hydrogenation techniques have further improved the efficiency and scalability of these processes, making 1-(2,3-Difluorophenyl)ethanol more accessible for large-scale applications.

In the pharmaceutical industry, 1-(2,3-Difluorophenyl)ethanol has shown promise as a key intermediate in the development of novel drugs. The presence of the difluorophenyl group can significantly influence the pharmacokinetic and pharmacodynamic properties of drug candidates. For instance, studies have demonstrated that fluorinated compounds often exhibit enhanced metabolic stability and improved binding affinity to target receptors. This makes 1-(2,3-Difluorophenyl)ethanol an attractive starting material for the synthesis of drugs targeting various diseases, including cancer, neurodegenerative disorders, and infectious diseases.

One notable application of 1-(2,3-Difluorophenyl)ethanol is in the development of antiviral agents. Recent research has focused on the design and synthesis of small molecules that can inhibit viral replication by targeting specific viral enzymes. The unique electronic properties of the difluorophenyl group have been shown to enhance the inhibitory activity of these compounds against a range of viruses, including influenza and HIV. This has led to several promising lead compounds that are currently undergoing preclinical evaluation.

Beyond its pharmaceutical applications, 1-(2,3-Difluorophenyl)ethanol has also found use in other areas of chemical research. For example, it serves as a versatile ligand in coordination chemistry and can be used to modify the properties of metal complexes for catalytic applications. The ability to fine-tune the electronic environment around the metal center through the introduction of fluorine atoms has opened up new possibilities for developing highly selective and efficient catalysts.

In materials science, 1-(2,3-Difluorophenyl)ethanol has been explored as a component in the synthesis of functional polymers and coatings. The presence of fluorine atoms can impart hydrophobic and oleophobic properties to these materials, making them suitable for applications such as self-cleaning surfaces and anti-fouling coatings. Additionally, the compound's ability to form stable hydrogen bonds with other molecules has been leveraged to create supramolecular assemblies with unique structural and functional characteristics.

The environmental impact of chemicals is an important consideration in their development and use. Recent studies have investigated the biodegradability and ecotoxicity of 1-(2,3-Difluorophenyl)ethanol. While preliminary results suggest that it is relatively non-toxic to aquatic organisms at low concentrations, further research is needed to fully understand its long-term environmental effects. Efforts are also underway to develop more sustainable synthetic methods for producing this compound using renewable resources and green chemistry principles.

In conclusion, 1-(2,3-Difluorophenyl)ethanol (CAS No. 1228690-56-9) is a multifaceted compound with a wide range of applications in pharmaceuticals, chemical research, materials science, and beyond. Its unique chemical properties make it an invaluable tool for researchers seeking to develop innovative solutions to pressing scientific challenges. As research continues to advance in these areas, the importance of compounds like 1-(2,3-Difluorophenyl)ethanol is likely to grow even further.

• 830-50-2(1-(Pentafluorophenyl)ethanol)
• 1944-05-4(2,3,4,5,6-PENTAFLUOROBENZHYDROL)
• 104371-20-2((1S)-1-(pentafluorophenyl)ethan-1-ol)
• 1766-76-3(Decafluorobenzhydrol)
• 104371-21-3((1R)-1-(pentafluorophenyl)ethan-1-ol)
• 75853-08-6(1-(Pentafluorophenyl)ethanol)
• 27599-16-2(Benzhydrol,pentafluoro- (8CI))
• 7583-08-6(1-(pentafluorophenyl)ethanol)
• 691881-96-6((1S)-1-(2,3-difluorophenyl)ethan-1-ol)
• 34216-87-0(Methyl, hydroxybis(pentafluorophenyl)-)