• 1. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 2. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 3. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 4. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 5. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369

2,5-Difluoro-4-(hydroxymethyl)pyridine (CAS No. 1227601-53-7): A Versatile Fluorinated Pyridine Derivative

2,5-Difluoro-4-(hydroxymethyl)pyridine (CAS No. 1227601-53-7) is a fluorinated pyridine derivative that has gained significant attention in pharmaceutical and agrochemical research. This compound, with its unique combination of fluorine substituents and a hydroxymethyl group, offers remarkable potential as a building block in drug discovery and material science. The presence of fluorine atoms at the 2 and 5 positions enhances the molecule's electronic properties, while the hydroxymethyl functionality provides a versatile handle for further chemical modifications.

The growing interest in fluorinated pyridine compounds like 2,5-Difluoro-4-(hydroxymethyl)pyridine stems from their importance in developing new therapeutic agents. Researchers are particularly interested in how the fluorine substitution pattern influences biological activity and metabolic stability. Recent studies have shown that such fluorinated heterocycles can improve drug-like properties, making them valuable scaffolds in medicinal chemistry. The compound's molecular weight of 145.11 g/mol and its balanced lipophilicity make it particularly attractive for CNS-targeted drug development.

In synthetic chemistry, 2,5-Difluoro-4-(hydroxymethyl)pyridine serves as a key intermediate for constructing more complex molecular architectures. The hydroxymethyl group can be readily converted to various functionalities, including aldehydes, carboxylic acids, or ethers, enabling diverse synthetic transformations. This versatility has made the compound particularly valuable in parallel synthesis and combinatorial chemistry approaches, where rapid access to molecular diversity is crucial.

The pharmaceutical applications of 2,5-Difluoro-4-(hydroxymethyl)pyridine are particularly noteworthy in the context of current drug discovery trends. With the increasing focus on targeted therapies and personalized medicine, researchers are exploring how such fluorinated building blocks can contribute to the development of kinase inhibitors, GPCR modulators, and epigenetic regulators. The compound's ability to modulate both the electronic and steric properties of drug candidates makes it especially valuable in structure-activity relationship studies.

From a material science perspective, 2,5-Difluoro-4-(hydroxymethyl)pyridine has shown promise in the development of advanced organic materials. The fluorine atoms can influence intermolecular interactions and packing arrangements, potentially leading to materials with unique electronic or optical properties. Researchers are investigating its use in liquid crystal displays, organic semiconductors, and other electronic applications where precise control of molecular properties is essential.

The synthesis of 2,5-Difluoro-4-(hydroxymethyl)pyridine typically involves selective fluorination strategies followed by hydroxymethylation. Modern synthetic approaches emphasize atom economy and green chemistry principles, reflecting the growing importance of sustainable chemistry practices. Recent advances in continuous flow chemistry have also been applied to the production of such fluorinated pyridine derivatives, offering improved safety profiles and scalability compared to traditional batch processes.

Analytical characterization of 2,5-Difluoro-4-(hydroxymethyl)pyridine typically involves a combination of NMR spectroscopy (particularly ¹⁹F NMR), mass spectrometry, and HPLC analysis. The distinct fluorine NMR signature of this compound provides valuable structural information and facilitates purity assessment. These analytical techniques are crucial for quality control in pharmaceutical applications where stringent purity standards must be met.

In the context of current research trends, 2,5-Difluoro-4-(hydroxymethyl)pyridine is being explored for its potential in COVID-19 related research, particularly as a building block for antiviral agents. While not directly active against the virus, its structural features make it an interesting candidate for incorporation into protease inhibitors or other antiviral scaffolds. This application aligns with the broader scientific community's focus on pandemic preparedness and antiviral drug development.

The commercial availability of 2,5-Difluoro-4-(hydroxymethyl)pyridine has improved in recent years, reflecting growing demand from both academic and industrial researchers. Suppliers typically offer the compound in research quantities with purity grades suitable for various applications. Proper storage conditions (typically 2-8°C under inert atmosphere) are recommended to maintain the stability of this hydroxymethyl-containing pyridine derivative over extended periods.

Looking forward, the applications of 2,5-Difluoro-4-(hydroxymethyl)pyridine are expected to expand as researchers continue to explore the unique properties of fluorinated heterocycles. Its combination of synthetic versatility and potential biological activity positions it as a valuable tool in drug discovery pipelines. As the pharmaceutical industry places greater emphasis on fluorine-containing compounds, the importance of such building blocks is likely to grow significantly in the coming years.

From a regulatory perspective, 2,5-Difluoro-4-(hydroxymethyl)pyridine is generally regarded as a research chemical with no significant restrictions for laboratory use. However, researchers should always consult local regulations and implement appropriate safety measures when handling any chemical substance. The compound's Material Safety Data Sheet (MSDS) provides detailed information about handling, storage, and disposal requirements.

In conclusion, 2,5-Difluoro-4-(hydroxymethyl)pyridine (CAS No. 1227601-53-7) represents an important class of fluorinated pyridine derivatives with wide-ranging applications in medicinal chemistry and material science. Its unique structural features, combining fluorine substituents with a hydroxymethyl group, make it a versatile building block for drug discovery and other advanced applications. As research into fluorine-containing compounds continues to expand, this compound is poised to play an increasingly significant role in scientific innovation.

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