• 1. Distributed research: a new paradigm for undergraduate research and global problem solving?
  Bruce Parkinson Energy Environ. Sci., 2010,3, 509-511
• 2. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
• 3. Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires?
  Daniel Messmer,Stefan Salentinig,Jakob Heier Nanoscale, 2019,11, 6929-6938
• 4. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 5. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064

Recent Advances in the Application of (5-Bromo-2-fluoropyridin-4-yl)methanol (CAS: 1227585-92-3) in Chemical Biology and Pharmaceutical Research

The compound (5-Bromo-2-fluoropyridin-4-yl)methanol (CAS: 1227585-92-3) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile applications as a key intermediate in the synthesis of bioactive molecules. This research briefing aims to provide a comprehensive overview of the latest advancements involving this compound, focusing on its synthetic utility, biological relevance, and potential therapeutic applications.

Recent studies have highlighted the role of (5-Bromo-2-fluoropyridin-4-yl)methanol as a crucial building block in the development of kinase inhibitors, particularly those targeting cancer-related pathways. The presence of both bromo and fluoro substituents on the pyridine ring enhances its reactivity in cross-coupling reactions, making it a valuable scaffold for medicinal chemistry. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated its use in the synthesis of novel Bruton's tyrosine kinase (BTK) inhibitors, which showed promising activity against B-cell malignancies.

In addition to its role in kinase inhibitor development, (5-Bromo-2-fluoropyridin-4-yl)methanol has been employed in the synthesis of positron emission tomography (PET) tracers. Researchers have utilized its bromo substituent for radiofluorination, enabling the creation of radiolabeled compounds for imaging applications. A recent publication in ACS Chemical Biology detailed its use in the development of a fluorine-18 labeled probe for imaging neuroinflammation, showcasing its potential in diagnostic applications.

The compound's unique chemical properties have also facilitated its use in fragment-based drug discovery (FBDD). Its small molecular weight and ability to form hydrogen bonds make it an ideal fragment for screening against various biological targets. A 2022 study in Bioorganic & Medicinal Chemistry Letters reported its successful incorporation into a fragment library, leading to the identification of novel hits against bacterial RNA polymerase.

From a synthetic chemistry perspective, recent advancements have focused on optimizing the preparation of (5-Bromo-2-fluoropyridin-4-yl)methanol to improve yield and purity. A 2023 patent application disclosed an improved synthetic route starting from 2-fluoro-4-bromopyridine, featuring a mild oxidation step that minimizes side product formation. This development is particularly significant for scaling up production to meet the growing demand in pharmaceutical research.

Looking forward, the versatility of (5-Bromo-2-fluoropyridin-4-yl)methanol continues to inspire new applications in drug discovery. Its combination of halogen substituents and alcohol functionality provides multiple points for structural modification, making it a valuable tool for medicinal chemists. Current research efforts are exploring its potential in targeted protein degradation strategies and covalent inhibitor design, areas that are rapidly gaining traction in pharmaceutical development.

In conclusion, (5-Bromo-2-fluoropyridin-4-yl)methanol (CAS: 1227585-92-3) remains a compound of significant interest in chemical biology and pharmaceutical research. Its diverse applications across drug discovery, diagnostic imaging, and synthetic methodology development underscore its importance as a versatile building block. As research continues to uncover new uses for this compound, it is expected to play an increasingly prominent role in the development of novel therapeutic agents and research tools.

• 864830-16-0(5-Bromo-2-fluoro-4-methylpyridine)
• 1000340-01-1(3,5-Dibromo-2-fluoro-4-methylpyridine)
• 1214375-45-7(Methyl 5-bromo-2-fluoroisonicotinate)
• 1805418-91-0(4-Bromo-2-fluoropyridine-5-methanol)
• 1214377-40-8(5-Bromo-2-fluoroisonicotinic Acid)
• 884495-46-9(3-Bromo-2-fluoro-4-methylpyridine)
• 1227601-79-7((3-Bromo-2-fluoropyridin-4-yl)methanol)
• 2624139-04-2(2-(5-Bromo-2-fluoropyridin-4-yl)ethan-1-ol)
• 1227588-77-3(5-Bromo-2-fluoroisonicotinaldehyde)
• 1214360-60-7(4-Pyridinecarboxylic acid, 3-bromo-2-fluoro-)