• 1. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
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• 2. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
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• 3. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
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• 4. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Comprehensive Overview of (2-Bromo-5-chloropyridin-3-yl)methanol (CAS No. 1227585-65-0)

(2-Bromo-5-chloropyridin-3-yl)methanol, with the CAS number 1227585-65-0, is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This compound belongs to the pyridine derivative family, characterized by its unique bromo and chloro substituents, which enhance its reactivity and utility in synthetic chemistry. Researchers and industry professionals often seek this compound for its potential applications in drug discovery, material science, and specialty chemical synthesis.

The molecular structure of (2-Bromo-5-chloropyridin-3-yl)methanol features a pyridine ring substituted with bromine at the 2-position and chlorine at the 5-position, along with a hydroxymethyl group at the 3-position. This arrangement makes it a versatile intermediate for constructing more complex molecules. Its CAS No. 1227585-65-0 is frequently searched in databases like SciFinder and Reaxys, reflecting its importance in modern chemical research.

In recent years, the demand for halogenated pyridine derivatives has surged due to their role in developing active pharmaceutical ingredients (APIs) and agrochemicals. The compound’s bromo and chloro groups are particularly valuable for cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, which are pivotal in creating carbon-carbon and carbon-nitrogen bonds. These reactions are central to the synthesis of biologically active molecules, making (2-Bromo-5-chloropyridin-3-yl)methanol a sought-after building block.

Another area where CAS No. 1227585-65-0 is gaining traction is in the development of electronic materials. Halogenated pyridines are known for their electron-withdrawing properties, which are beneficial in designing organic semiconductors and light-emitting diodes (OLEDs). Researchers are exploring how the hydroxymethyl group in this compound can be further functionalized to tailor materials with specific electronic properties.

From a synthetic chemistry perspective, the stability and reactivity of (2-Bromo-5-chloropyridin-3-yl)methanol make it a reliable candidate for multi-step synthesis. Its CAS No. 1227585-65-0 is often referenced in patents and academic papers, highlighting its role in innovative chemical processes. For instance, it has been used in the synthesis of heterocyclic compounds, which are prevalent in many FDA-approved drugs.

Environmental and safety considerations are also critical when working with halogenated compounds. While (2-Bromo-5-chloropyridin-3-yl)methanol is not classified as hazardous under standard regulations, proper handling and disposal protocols should always be followed. This aligns with the growing industry focus on green chemistry and sustainable synthesis, topics frequently searched by professionals aiming to minimize environmental impact.

In summary, (2-Bromo-5-chloropyridin-3-yl)methanol (CAS No. 1227585-65-0) is a multifaceted compound with broad applications in pharmaceuticals, agrochemicals, and materials science. Its unique structural features and reactivity profile make it indispensable for researchers tackling challenges in drug development, material design, and synthetic methodology. As the chemical industry evolves, this compound is poised to remain a key player in advancing scientific and technological innovations.

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