• 1. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 2. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 3. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 4. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 5. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Alkyl aryl ethers

Recent Advances in the Application of 2,4-Dimethoxy-5-methylpyridine (CAS: 1227574-94-8) in Chemical Biology and Pharmaceutical Research

2,4-Dimethoxy-5-methylpyridine (CAS: 1227574-94-8) has recently emerged as a compound of significant interest in chemical biology and pharmaceutical research. This heterocyclic aromatic compound, characterized by its methoxy and methyl substituents, has demonstrated versatile applications in drug discovery, medicinal chemistry, and material science. Recent studies have highlighted its potential as a key intermediate in the synthesis of bioactive molecules and its role in modulating biological targets.

One of the most notable applications of 2,4-dimethoxy-5-methylpyridine is its use as a building block in the synthesis of kinase inhibitors. A 2023 study published in the *Journal of Medicinal Chemistry* demonstrated its utility in the development of selective inhibitors for tyrosine kinases, which are implicated in various cancers. The study reported that derivatives of 2,4-dimethoxy-5-methylpyridine exhibited potent inhibitory activity against specific kinase isoforms, with IC50 values in the nanomolar range. This finding underscores the compound's potential in targeted cancer therapy.

In addition to its role in kinase inhibition, 2,4-dimethoxy-5-methylpyridine has been investigated for its applications in photopharmacology. A recent preprint on *bioRxiv* described the incorporation of this compound into light-sensitive prodrugs, enabling spatiotemporal control of drug activation. The researchers utilized the compound's unique electronic properties to design prodrugs that release active therapeutic agents upon exposure to specific wavelengths of light. This approach holds promise for reducing off-target effects and improving therapeutic precision.

Another area of active research involves the use of 2,4-dimethoxy-5-methylpyridine in the synthesis of novel antimicrobial agents. A 2024 study in *ACS Infectious Diseases* reported the development of pyridine-based small molecules with broad-spectrum activity against drug-resistant bacterial strains. The study highlighted the compound's ability to disrupt bacterial cell membranes and inhibit essential metabolic pathways, making it a valuable scaffold for antibiotic development.

Beyond its biological applications, 2,4-dimethoxy-5-methylpyridine has also found use in materials science. Researchers have explored its incorporation into organic semiconductors and photovoltaic materials due to its electron-donating properties. A recent publication in *Advanced Materials* detailed the synthesis of pyridine-based polymers with enhanced charge transport characteristics, paving the way for more efficient organic electronic devices.

In conclusion, 2,4-dimethoxy-5-methylpyridine (CAS: 1227574-94-8) represents a versatile and promising compound in chemical biology and pharmaceutical research. Its applications span drug discovery, photopharmacology, antimicrobial development, and materials science, reflecting its broad utility. Ongoing research continues to uncover new roles for this compound, highlighting its potential to address unmet medical and technological challenges.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)