• 1. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 2. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 5. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625

Comprehensive Overview of 2-Methoxy-5-methylpyridine-3-acetonitrile (CAS No. 1227515-63-0)

2-Methoxy-5-methylpyridine-3-acetonitrile (CAS No. 1227515-63-0) is a specialized organic compound widely recognized for its versatile applications in pharmaceutical intermediates and agrochemical synthesis. This compound, characterized by its pyridine core structure, features a methoxy group at the 2-position and a methyl group at the 5-position, with an acetonitrile moiety at the 3-position. Its unique molecular architecture makes it a valuable building block in modern synthetic chemistry, particularly in the development of bioactive molecules.

The growing interest in 2-Methoxy-5-methylpyridine-3-acetonitrile is driven by its role in the synthesis of heterocyclic compounds, which are pivotal in drug discovery. Researchers frequently search for "pyridine derivatives in drug design" or "acetonitrile applications in pharmaceuticals," highlighting the compound's relevance in cutting-edge research. Its stability and reactivity under mild conditions further enhance its utility in catalytic reactions and multi-step organic synthesis.

From an industrial perspective, CAS No. 1227515-63-0 is often employed in the production of crop protection agents and specialty chemicals. With increasing global demand for sustainable agriculture, queries like "eco-friendly agrochemical intermediates" or "green synthesis of pyridine compounds" reflect the compound's alignment with environmental trends. Manufacturers prioritize high-purity grades of this chemical to ensure optimal performance in pesticide formulations and herbicide development.

Analytical studies of 2-Methoxy-5-methylpyridine-3-acetonitrile typically involve advanced techniques such as HPLC, GC-MS, and NMR spectroscopy. These methods confirm its structural integrity and purity, addressing common user concerns like "how to verify pyridine derivative purity" or "analytical methods for nitrile compounds." The compound's solubility profile (soluble in organic solvents like dichloromethane and ethanol) and melting point characteristics are critical parameters for laboratory applications.

In the context of material science, this pyridine derivative has shown promise in coordination chemistry and ligand design. Searches related to "nitrile-containing ligands for catalysis" or "methoxy-pyridine metal complexes" underscore its potential in developing novel catalytic systems. Its electron-withdrawing cyano group and electron-donating methoxy group create a balanced electronic environment, facilitating diverse chemical transformations.

Safety and handling protocols for CAS No. 1227515-63-0 emphasize standard laboratory practices, including the use of personal protective equipment (PPE) and proper ventilation. While not classified as hazardous under normal conditions, its storage recommendations (cool, dry place away from oxidizers) align with frequently asked questions like "best practices for storing nitrile compounds." Regulatory compliance, particularly concerning REACH and FDA guidelines, is another key area of user interest.

The future prospects of 2-Methoxy-5-methylpyridine-3-acetonitrile are closely tied to advancements in precision medicine and green chemistry. Emerging trends such as "AI-assisted molecular design" and "biocatalytic synthesis routes" may further expand its applications. As synthetic methodologies evolve, this compound is poised to remain a cornerstone in the development of high-value fine chemicals and tailored molecular architectures.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)