• 1. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 2. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 3. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 4. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 5. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Bromobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Bromobenzenes

4-(3-Bromophenyl)-4-hydroxybutanenitrile (CAS 1225729-11-2): A Comprehensive Overview of Properties and Applications

4-(3-Bromophenyl)-4-hydroxybutanenitrile (CAS 1225729-11-2) is an important organic compound that has garnered significant attention in pharmaceutical and chemical research. This brominated phenyl derivative exhibits unique structural features that make it valuable for various synthetic applications. The compound's molecular formula is C10H10BrNO, with a molecular weight of 240.10 g/mol.

The hydroxybutanenitrile moiety in 4-(3-Bromophenyl)-4-hydroxybutanenitrile provides excellent reactivity for further chemical transformations, while the bromophenyl group offers opportunities for cross-coupling reactions. Recent studies in medicinal chemistry have highlighted its potential as a building block for drug discovery, particularly in the development of CNS-targeting compounds and enzyme inhibitors.

From a physicochemical perspective, 4-(3-Bromophenyl)-4-hydroxybutanenitrile typically appears as a white to off-white crystalline powder. Its solubility profile shows good dissolution in polar organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO), while being less soluble in water. The compound's melting point range and stability characteristics make it suitable for various synthetic protocols under controlled conditions.

In pharmaceutical applications, researchers have explored 4-(3-Bromophenyl)-4-hydroxybutanenitrile as a precursor for several bioactive molecules. Its structural features allow for the development of compounds with potential neuroprotective effects and anti-inflammatory properties. The presence of both hydroxyl and nitrile functional groups enables diverse modification possibilities, making it a versatile intermediate in drug design.

The synthetic chemistry applications of 4-(3-Bromophenyl)-4-hydroxybutanenitrile extend to its use in palladium-catalyzed coupling reactions, where the bromine atom serves as an excellent leaving group. This characteristic has made it valuable in the construction of complex molecular architectures, particularly in the synthesis of heterocyclic compounds and functionalized arenes.

Recent advancements in green chemistry have explored more sustainable approaches to working with brominated compounds like 4-(3-Bromophenyl)-4-hydroxybutanenitrile. Researchers are investigating catalyst systems that can improve the atom economy of reactions involving this intermediate, addressing growing concerns about environmental impact in chemical synthesis.

From a market perspective, the demand for 4-(3-Bromophenyl)-4-hydroxybutanenitrile has shown steady growth, particularly from contract research organizations and pharmaceutical development companies. The compound's availability in various purity grades (typically 95% to 99%) allows for different research and production needs. Current supply chain analysis indicates that specialized chemical manufacturers are the primary sources for this intermediate.

Quality control of 4-(3-Bromophenyl)-4-hydroxybutanenitrile typically involves HPLC analysis, NMR spectroscopy, and mass spectrometry to ensure purity and confirm structural integrity. These analytical methods are crucial for applications in drug discovery where compound purity directly impacts research outcomes. Proper storage conditions (typically 2-8°C in airtight containers) are recommended to maintain the compound's stability over time.

The intellectual property landscape surrounding 4-(3-Bromophenyl)-4-hydroxybutanenitrile includes several patents describing its use in various synthetic routes and as an intermediate for specific therapeutic agents. Researchers and manufacturers should conduct proper patent searches before developing new applications involving this compound to avoid infringement issues.

Future research directions for 4-(3-Bromophenyl)-4-hydroxybutanenitrile may focus on expanding its utility in asymmetric synthesis and developing more efficient preparation methods. The compound's potential in bioconjugation chemistry and as a scaffold for molecular probes represents promising areas for further investigation. As the pharmaceutical industry continues to seek novel building blocks for drug development, brominated intermediates like this compound will likely maintain their importance in medicinal chemistry.

For researchers working with 4-(3-Bromophenyl)-4-hydroxybutanenitrile, proper safety protocols should always be followed, including the use of appropriate personal protective equipment and engineering controls. While not classified as highly hazardous, standard precautions for handling organic compounds should be observed to ensure safe laboratory practices.

In conclusion, 4-(3-Bromophenyl)-4-hydroxybutanenitrile (CAS 1225729-11-2) represents a valuable chemical intermediate with diverse applications in pharmaceutical research and organic synthesis. Its unique combination of functional groups and reactivity profile continues to make it an important tool for chemists developing new molecules with potential biological activity. As synthetic methodologies advance and drug discovery efforts expand, this compound will likely remain relevant in chemical research for years to come.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)