Cas no 1224439-44-4 (4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8)

4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8 is a deuterated organosilicon compound used primarily as a labeled intermediate in synthetic chemistry and pharmaceutical research. The incorporation of deuterium (d8) enhances its utility in isotopic labeling studies, providing improved stability and traceability in metabolic and kinetic investigations. The dimethyl-t-butylsilyl (TBS) protecting group offers selective deprotection under mild conditions, making it valuable for controlled synthetic applications. Its structural features facilitate precise modifications in complex molecular frameworks, particularly in nucleoside and carbohydrate chemistry. The compound’s high purity and defined isotopic labeling ensure reliability in analytical applications, including NMR and mass spectrometry.
4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8 structure
1224439-44-4 structure
Product Name:4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8
CAS No:1224439-44-4
MF:C9H22O2Si
MW:196.39225435257
CID:1003150
PubChem ID:71777166
Update Time:2025-06-12

4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8 Chemical and Physical Properties

Names and Identifiers

    • 3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1-propanol-d6
    • 3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1-propan-1,1,2,2,3,3-d6-ol
    • 4-(tert-butyldimethylsilyloxy)butan-d8-1-ol
    • 1224439-44-4
    • DB-304327
    • 4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8
    • Inchi： 1S/C9H22O2Si/c1-9(2,3)12(4,5)11-8-6-7-10/h10H,6-8H2,1-5H3/i6D2,7D2,8D2
    • InChI Key： NETUFVYVNJNFMU-JEKPXRCASA-N
    • SMILES： [Si](C)(C)(C(C)(C)C)OC([2H])([2H])C([2H])([2H])C([2H])([2H])O

Computed Properties

  • Exact Mass: 196.176566950g/mol
  • Monoisotopic Mass: 196.176566950g/mol
  • Isotope Atom Count: 6
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 5
  • Complexity: 127
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 29.5?2

4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8 Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
D468262-10mg
4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8
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10mg
 $75.00 2023-05-18
TRC
D468262-25mg
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 $155.00 2023-05-18
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D468262-50mg
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50mg
 $282.00 2023-05-18
TRC
D468262-100mg
4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8
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100mg
 $534.00 2023-05-18
TRC
D468262-250mg
4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8
 1224439-44-4
250mg
 $1194.00 2023-05-18

4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8 Related Literature

Additional information on 4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8

Comprehensive Overview of 4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8 (CAS No. 1224439-44-4): Applications and Insights

The compound 4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8 (CAS No. 1224439-44-4) is a deuterated derivative of a silyl-protected alcohol, widely utilized in pharmaceutical research, organic synthesis, and isotopic labeling studies. Its unique structure, featuring a dimethyl-t-butylsilyl (TBS) protecting group and deuterium substitution, makes it invaluable for metabolic stability testing and NMR spectroscopy. As the demand for deuterated compounds grows in drug discovery, this molecule has garnered significant attention for its role in enhancing drug half-life and reducing toxicity.

In recent years, the focus on deuterium-labeled compounds has surged due to their applications in precision medicine and bioavailability optimization. Researchers frequently search for terms like "deuterated alcohol synthesis" or "TBS-protected deuterium reagents," reflecting the compound's relevance in modern chemistry. The CAS No. 1224439-44-4 is particularly noted for its stability under acidic conditions, making it a preferred choice for multi-step organic reactions.

From a synthetic perspective, 4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8 serves as a versatile intermediate in the preparation of deuterated pharmaceuticals. Its TBS group offers robust protection for hydroxyl functionalities, while the deuterium atoms enable isotopic tracing in pharmacokinetic studies. This dual functionality aligns with the rising trend of "deuterium in drug design," a hot topic in medicinal chemistry forums and publications.

Environmental and regulatory considerations also play a role in the compound's adoption. Unlike non-deuterated analogs, deuterium-enriched molecules often exhibit improved metabolic profiles, reducing the risk of harmful byproducts. This aligns with the increasing emphasis on green chemistry and sustainable synthesis, addressing concerns about chemical waste and eco-friendly processes.

In conclusion, 4-(Dimethyl-t-butylsilyloxy)butan-1-ol-d8 (CAS No. 1224439-44-4) represents a critical tool for researchers exploring isotope effects and drug development. Its applications span from NMR solvent systems to proteomics research, underscoring its interdisciplinary importance. As the scientific community continues to prioritize deuterium incorporation, this compound will remain at the forefront of innovative solutions in life sciences and beyond.

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