Cas no 122111-05-1 (1’-Epi Gemcitabine Hydrochloride)
1’-Epi Gemcitabine Hydrochloride Chemical and Physical Properties
Names and Identifiers
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- 2(1H)-Pyrimidinone,4-amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-, hydrochloride (1:1)
- 4-Amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride
- 1’-EPI GEMCITABINE HYDROCHLORIDE
- 2(1H)-Pyrimidinone,4-amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-, hydrochloride...
- 4-amino-1-[(2S,4S,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one,hydrochloride
- 1'-Epi Gemcitabine Hydrochloride
- 2'-deoxy-2',2'-difluorocytidine hydrochloride
- A-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride
- Gemcitabine (alpha-Isomer) HCl
- Gemcitabine (alpha-Isomer) Hydrochloride
- 4-AMino-1-(2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl)-2(1H)-pyriMidinone Hydrochloride
- 4-amino-1-((2S,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride
- DTXSID70675880
- 4-amino-1-[(2S,4S,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride
- J-004763
- 1'-Epi Gemcitabine (hydrochloride)
- 122111-05-1
- HY-B0003A
- CS-0113839
- 4-Amino-1-(2-deoxy-2,2-difluoro-alpha-D-threo-pentofuranosyl)pyrimidin-2(1H)-one--hydrogen chloride (1/1)
- 4-amino-1-[(2S,4S,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one hydrochloride
- AKOS030241366
- 1’-Epi Gemcitabine Hydrochloride
-
- Inchi： 1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6+,7+;/m1./s1
- InChI Key： OKKDEIYWILRZIA-DNSZWREKSA-N
- SMILES： Cl.FC1([C@@H](N2C(N=C(C=C2)N)=O)O[C@H](CO)[C@@H]1O)F
Computed Properties
- Exact Mass: 299.04800
- Monoisotopic Mass: 299.048
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 4
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 19
- Rotatable Bond Count: 2
- Complexity: 426
- Covalently-Bonded Unit Count: 2
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 3
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 108A^2
Experimental Properties
- Melting Point: 204-206°C
- PSA: 110.60000
- LogP: 0.09460
1’-Epi Gemcitabine Hydrochloride Security Information
- Storage Condition：-20°C Freezer, Under Inert Atmosphere
1’-Epi Gemcitabine Hydrochloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | E588510-5mg |
1’-Epi Gemcitabine Hydrochloride |
122111-05-1 | 5mg |
$230.00 | 2023-05-18 | ||
| TRC | E588510-10mg |
1’-Epi Gemcitabine Hydrochloride |
122111-05-1 | 10mg |
$ 413.00 | 2023-09-07 | ||
| TRC | E588510-25mg |
1’-Epi Gemcitabine Hydrochloride |
122111-05-1 | 25mg |
$ 917.00 | 2023-09-07 | ||
| TRC | E588510-50mg |
1’-Epi Gemcitabine Hydrochloride |
122111-05-1 | 50mg |
$ 1777.00 | 2023-09-07 | ||
| TRC | E952510-10mg |
1’-Epi Gemcitabine Hydrochloride (≥98%) |
122111-05-1 | 10mg |
$1745.00 | 2023-05-18 | ||
| TRC | E952510-1mg |
1’-Epi Gemcitabine Hydrochloride (≥98%) |
122111-05-1 | 1mg |
$224.00 | 2023-05-18 | ||
| TRC | E952510-5mg |
1’-Epi Gemcitabine Hydrochloride (≥98%) |
122111-05-1 | 5mg |
$994.00 | 2023-05-18 | ||
| A2B Chem LLC | AD59058-1mg |
1'-Epi Gemcitabine Hydrochloride |
122111-05-1 | 1mg |
$266.00 | 2024-04-20 | ||
| A2B Chem LLC | AD59058-5mg |
1'-Epi Gemcitabine Hydrochloride |
122111-05-1 | 5mg |
$681.00 | 2024-04-20 | ||
| A2B Chem LLC | AD59058-10mg |
1'-Epi Gemcitabine Hydrochloride |
122111-05-1 | 10mg |
$1068.00 | 2024-04-20 |
1’-Epi Gemcitabine Hydrochloride Suppliers
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1’-Epi Gemcitabine Hydrochloride Related Literature
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1. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
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Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
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Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
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Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
Additional information on 1’-Epi Gemcitabine Hydrochloride
1’-Epi Gemcitabine Hydrochloride (CAS No. 122111-05-1): A Comprehensive Overview
1’-Epi Gemcitabine Hydrochloride (CAS No. 122111-05-1) is a stereoisomer of the well-known anticancer drug Gemcitabine Hydrochloride. This compound has garnered significant attention in pharmaceutical research due to its unique structural properties and potential therapeutic applications. As the demand for novel cancer treatments continues to rise, researchers are increasingly exploring derivatives like 1’-Epi Gemcitabine Hydrochloride to enhance efficacy and reduce side effects.
The chemical structure of 1’-Epi Gemcitabine Hydrochloride features a modified sugar moiety compared to its parent compound, which may influence its pharmacokinetics and pharmacodynamics. This subtle yet critical difference has sparked interest in its potential to overcome drug resistance, a major challenge in oncology. Recent studies suggest that 1’-Epi Gemcitabine Hydrochloride could exhibit improved stability and bioavailability, making it a promising candidate for further development.
In the context of current cancer research trends, 1’-Epi Gemcitabine Hydrochloride aligns with the growing focus on personalized medicine and targeted therapies. Researchers are investigating its mechanism of action, particularly its interaction with DNA synthesis pathways, to determine its suitability for specific cancer types. The compound's potential to synergize with other anticancer agents is also under scrutiny, as combination therapies often yield better outcomes than monotherapies.
The synthesis of 1’-Epi Gemcitabine Hydrochloride involves sophisticated chemical processes to ensure high purity and yield. Analytical techniques such as HPLC and NMR spectroscopy are routinely employed to characterize the compound and verify its stereochemical configuration. Quality control is paramount, given the compound's intended use in preclinical and clinical studies.
From a market perspective, the demand for 1’-Epi Gemcitabine Hydrochloride is driven by the expanding oncology drug pipeline and the need for innovative treatments. Pharmaceutical companies and research institutions are actively sourcing high-quality reference standards and intermediates to support their R&D efforts. The compound's niche status and specialized applications contribute to its premium positioning in the market.
One of the most frequently asked questions about 1’-Epi Gemcitabine Hydrochloride relates to its comparative efficacy versus Gemcitabine Hydrochloride. While preliminary data are encouraging, comprehensive clinical trials are needed to establish its therapeutic profile definitively. Another common query concerns the availability of 1’-Epi Gemcitabine Hydrochloride for research purposes, with many suppliers offering custom synthesis services to meet diverse project requirements.
In summary, 1’-Epi Gemcitabine Hydrochloride (CAS No. 122111-05-1) represents a fascinating area of exploration in medicinal chemistry and oncology. Its unique properties, combined with the pressing need for advanced cancer therapies, make it a compound of significant interest. As research progresses, 1’-Epi Gemcitabine Hydrochloride may well emerge as a valuable addition to the arsenal of anticancer agents, offering new hope for patients and clinicians alike.
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