• 1. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584
• 2. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 3. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 4. An amorphous lanthanum–iridium solid solution with an open structure for efficient water splitting?
  Wei Sun,Chenglong Ma,Xinlong Tian,Jianjun Liao,Ji Yang,Chengjun Ge,Weiwei Huang J. Mater. Chem. A, 2020,8, 12518-12525
• 5. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

Comprehensive Overview of N-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (CAS No. 1220696-19-4)

The compound N-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (CAS No. 1220696-19-4) is a boronic ester derivative with significant applications in organic synthesis, pharmaceuticals, and material science. Its unique structure, featuring a pyridine core and a dioxaborolane moiety, makes it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions, a topic frequently searched by chemists and researchers. The CAS number 1220696-19-4 is often queried in databases for precise identification, reflecting its growing importance in modern chemistry.

One of the most searched questions related to this compound is: "What are the applications of N-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine in drug discovery?" This highlights the interest in its role as a building block for bioactive molecules. The boronic ester group is pivotal in creating carbon-carbon bonds, enabling the synthesis of complex molecules like kinase inhibitors and antiviral agents. Researchers also explore its potential in proteolysis-targeting chimeras (PROTACs), a hot topic in targeted protein degradation therapies.

Another trending topic is the use of CAS 1220696-19-4 in OLED materials. The pyridine-boronate structure contributes to electron transport properties, making it valuable for light-emitting diodes. Queries like "How does N-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine enhance OLED efficiency?" underscore its relevance in sustainable technology. The compound’s stability under ambient conditions is another frequently discussed advantage, reducing storage challenges compared to other boronic acids.

From a synthetic perspective, the dioxaborolane group in CAS 1220696-19-4 offers improved solubility in organic solvents, a feature often searched by process chemists optimizing reaction conditions. Questions like "What solvents are compatible with N-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine?" are common in forums. The compound’s compatibility with tetrahydrofuran (THF) and dimethylformamide (DMF) is well-documented, facilitating its use in large-scale reactions.

Environmental and safety considerations are also trending. While the compound is not classified as hazardous, queries such as "Is CAS 1220696-19-4 biodegradable?" reflect the growing emphasis on green chemistry. Its low toxicity profile and stability make it a preferred choice over reactive boronic acids, aligning with industry demands for safer reagents.

In summary, N-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (CAS No. 1220696-19-4) bridges multiple disciplines, from medicinal chemistry to materials science. Its adaptability to Suzuki couplings, role in drug design, and contributions to advanced materials ensure its continued relevance in research and industrial applications. As interest in boron chemistry grows, this compound remains a focal point for innovation.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)