Cas no 1220219-22-6 (2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl)benzonitrile)

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile is a boronic ester derivative commonly employed as an intermediate in Suzuki-Miyaura cross-coupling reactions. The presence of the electron-withdrawing nitrile group and the methoxy substituent enhances its reactivity in palladium-catalyzed transformations, making it valuable for constructing complex aromatic systems. The pinacol boronate group offers stability under ambient conditions while remaining highly reactive in coupling reactions. This compound is particularly useful in pharmaceutical and materials science research for synthesizing functionalized biaryl structures. Its crystalline nature and moderate solubility in organic solvents facilitate handling and purification. Care should be taken to store it under inert conditions to prevent hydrolysis of the boronate moiety.
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl)benzonitrile structure
1220219-22-6 structure
Product Name:2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl)benzonitrile
CAS No:1220219-22-6
MF:C14H18BNO3
MW:259.108623981476
MDL:MFCD18383804
CID:3163983
PubChem ID:59534973
Update Time:2025-06-06

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl)benzonitrile Chemical and Physical Properties

Names and Identifiers

    • 2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile
    • SCHEMBL1667913
    • (3-cyano-4-methoxyphenyl)boronic acid pinacol ester
    • VYB21922
    • 2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile
    • AKOS027420915
    • BS-51039
    • CS-0089499
    • Z2044764586
    • DB-093819
    • 2-methoxy-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
    • EN300-1706499
    • 1220219-22-6
    • SEQGLOXOYMXKLY-UHFFFAOYSA-N
    • 3-Cyano-4-methoxyphenylboronic acid pinacol ester
    • MFCD18383804
    • 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl)benzonitrile
    • MDL： MFCD18383804
    • Inchi： 1S/C14H18BNO3/c1-13(2)14(3,4)19-15(18-13)11-6-7-12(17-5)10(8-11)9-16/h6-8H,1-5H3
    • InChI Key： SEQGLOXOYMXKLY-UHFFFAOYSA-N
    • SMILES： O1B(C2C=CC(=C(C#N)C=2)OC)OC(C)(C)C1(C)C

Computed Properties

  • Exact Mass: 259.1379736g/mol
  • Monoisotopic Mass: 259.1379736g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 19
  • Rotatable Bond Count: 2
  • Complexity: 371
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 51.5?2

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl)benzonitrile Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
M268863-50mg
2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile
 1220219-22-6
50mg
 $ 70.00 2022-06-02
TRC
M268863-100mg
2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile
 1220219-22-6
100mg
 $ 95.00 2022-06-02
TRC
M268863-500mg
2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile
 1220219-22-6
500mg
 $ 365.00 2022-06-02
ChemScence
CS-0089499-100mg
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
 1220219-22-6 ≥97.0%
100mg
 $74.0 2022-04-28
ChemScence
CS-0089499-250mg
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
 1220219-22-6 ≥97.0%
250mg
 $118.0 2022-04-28
ChemScence
CS-0089499-1g
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
 1220219-22-6 ≥97.0%
1g
 $356.0 2022-04-28
Alichem
A019100794-1g
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
 1220219-22-6 95%
1g
 $562.00 2023-09-03
Chemenu
CM206057-1g
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
 1220219-22-6 97%
1g
 $218 2023-02-03
Chemenu
CM206057-100mg
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
 1220219-22-6 97%
100mg
 $53 2023-02-03
Chemenu
CM206057-250mg
2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
 1220219-22-6 97%
250mg
 $84 2023-02-03

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2dioxaborolan-2-yl)benzonitrile Related Literature

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