Cas no 122-96-3 (1,4-Piperazinediethanol)
1,4-Piperazinediethanol Chemical and Physical Properties
Names and Identifiers
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- 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
- 1,4'-Bis(2-hydroxyethyl)piperazine
- 1,4-Piperazinediethanol
- 2,2'-(Piperazine-1,4-diyl)diethanol
- 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanol
- 1,4-Di(2-hydroxyethyl)piperazine
- AKOS BB-4936
- N,N'-PIPERAZINDIETHANOL
- N,N'-PIPERAZINEDIETHANOL
- piperazine-1,4-diethanol
- Piperazine-1,4-bisethanol
- DI(HYDROXYETHYL)PIPERAZINE
- N,N'-Dihydroxyethylpiperazine
- 1,4-BIS(2-HYDROXYETH
- N,N'-Bis(2-hydroxyethyl)piperazine
- N,N'-Di(2-hydroxyethyl)piperazine
- Piperazine, N,N'-bis(2-hydroxyethyl)-
- 1,4-Bis(beta-hydroxyethyl)piperazine
- N,N'-Bis(beta-hydroxyethyl)piperazine
- EQ349PKX8Y
- VARKIGWTYBUW
- BRN 0108245
- CBDivE_015046
- NSC 36645
- NSC36645
- EN300-7394810
- NSC-26892
- WLN: T6N DNTJ A2Q D2Q
- NSC 31268
- NSC 26892
- AI3-03876
- 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethan-1-ol
- 2,2'-piperazine-1,4-diyldiethanol
- di(N-Hydroxyethyl)piperazine
- N,N'-bis (2-hydroxyethyl) piperazine
- Tox21_200471
- FT-0631710
- W-109457
- 2-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-ethanol
- MFCD00006157
- DS-1913
- NS00019423
- NSC-36645
- UNII-EQ349PKX8Y
- AC-24659
- NCGC00248642-01
- NSC31268
- CS-W017493
- DTXSID3029158
- N,N'-Bis(.beta.-hydroxyethyl)piperazine
- Oprea1_826804
- DTXCID809158
- SY051663
- CHEMBL118235
- 122-96-3
- 1,4-Bis(.beta.-hydroxyethyl)piperazine
- SCHEMBL154974
- 1,4-Bis(2-hydroxyethyl)piperazine, 98%
- Piperazine,N'-bis(2-hydroxyethyl)-
- CAS-122-96-3
- DVQ
- B4903
- NCGC00258025-01
- NSC26892
- EINECS 204-586-0
- N,N'-bis-(2-hydroxyethyl)-piperazine
- NSC-31268
- AKOS003591075
- 1,4-Bis(2-hydroxyethyl)piperazine, 99%
- AMY40594
- Q27277296
- Piperazine, N,N'bis(2hydroxyethyl)
- 5-23-01-00484 (Beilstein Handbook Reference)
- N,N'Dihydroxyethylpiperazine
- 1,4Bis(2hydroxyethyl)piperazine
- N,N'Bis(2hydroxyethyl)piperazine
- 1,4-Bis(2-hydroxyethyl)piperazine; 1,4-Bis(hydroxyethyl)piperazine; 1,4-Bis(?-hydroxyethyl)piperazine; 1,4-Di(2-hydroxyethyl)piperazine; N,N'-Bis(2-hydroxyethyl)piperazine; 2,2'-(Piperazine-1,4,-diyl)diethanol
- STK500093
- DB-041699
- 1,4Bis(betahydroxyethyl)piperazine
- N,N'Bis(betahydroxyethyl)piperazine
- N,N'Di(2hydroxyethyl)piperazine
- 1,4Di(2hydroxyethyl)piperazine
-
- MDL： MFCD00006157
- Inchi： 1S/C8H18N2O2/c11-7-5-9-1-2-10(4-3-9)6-8-12/h11-12H,1-8H2
- InChI Key： VARKIGWTYBUWNT-UHFFFAOYSA-N
- SMILES： OCCN1CCN(CCO)CC1
- BRN： 0108245
Computed Properties
- Exact Mass: 174.13700
- Monoisotopic Mass: 174.137
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 12
- Rotatable Bond Count: 4
- Complexity: 99.6
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: -1.3
- Topological Polar Surface Area: 46.9
Experimental Properties
- Color/Form: No data available
- Density: 1.097
- Melting Point: 136.0 to 140.0 deg-C
- Boiling Point: 278°C(lit.)
- Flash Point: 166 oC
- Refractive Index: 1.4540 (estimate)
- Water Partition Coefficient: Soluble in water.
- PSA: 46.94000
- LogP: -1.53560
1,4-Piperazinediethanol Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Warning
- Hazard Statement： H303-H315-H319
- Warning Statement： P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P312
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 36/37/38
- Safety Instruction： S37/39-S26
- RTECS：TL3675000
-
Hazardous Material Identification：
- Safety Term：S26;S37/39
- Risk Phrases：R36/37/38
- TSCA：Yes
- Storage Condition：Sealed in dry,Room Temperature
1,4-Piperazinediethanol Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | B828538-500g |
1,4-Bis(2-hydroxyethyl)piperazine |
122-96-3 | 98% | 500g |
1,627.00 | 2021-05-17 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | B45402-5G |
1,4-Piperazinediethanol |
122-96-3 | 5g |
￥451.03 | 2023-11-14 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | B45402-25G |
1,4-Piperazinediethanol |
122-96-3 | 25g |
￥1345.51 | 2023-11-14 | ||
| Fluorochem | 209651-1g |
2,2'-(Piperazine-1,4-diyl)diethanol |
122-96-3 | >95% | 1g |
￡10.00 | 2022-02-28 | |
| Fluorochem | 209651-10g |
2,2'-(Piperazine-1,4-diyl)diethanol |
122-96-3 | >95% | 10g |
￡11.00 | 2022-02-28 | |
| Fluorochem | 209651-25g |
2,2'-(Piperazine-1,4-diyl)diethanol |
122-96-3 | >95% | 25g |
￡22.00 | 2022-02-28 | |
| Fluorochem | 209651-100g |
2,2'-(Piperazine-1,4-diyl)diethanol |
122-96-3 | >95% | 100g |
￡57.00 | 2022-02-28 | |
| Chemenu | CM169856-500g |
2,2'-(Piperazine-1,4-diyl)diethanol |
122-96-3 | 97% | 500g |
$224 | 2021-08-05 | |
| Chemenu | CM169856-1000g |
2,2'-(Piperazine-1,4-diyl)diethanol |
122-96-3 | 97% | 1000g |
$374 | 2021-08-05 | |
| TRC | P475343-1g |
1,4-Piperazinediethanol |
122-96-3 | 1g |
$ 46.00 | 2023-09-06 |
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1,4-Piperazinediethanol Related Literature
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Onome Ugono,Nigam P. Rath,Alicia M. Beatty CrystEngComm 2011 13 753
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Chris Ritchie,Thomas Boyd,De-Liang Long,Evert Ditzel,Leroy Cronin Dalton Trans. 2009 1587
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John F. Quinn,Michael R. Whittaker,Thomas P. Davis Polym. Chem. 2017 8 97
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Cheng-Cheng Song,Fu-Sheng Du,Zi-Chen Li J. Mater. Chem. B 2014 2 3413
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Cheng-Cheng Song,Fu-Sheng Du,Zi-Chen Li J. Mater. Chem. B 2014 2 3413
Additional information on 1,4-Piperazinediethanol
Recent Advances in the Research and Applications of 1,4-Piperazinediethanol (CAS: 122-96-3)
1,4-Piperazinediethanol (CAS: 122-96-3) is a chemical compound with significant relevance in the fields of chemical biology and pharmaceutical research. Recent studies have highlighted its versatile applications, particularly in drug design, polymer chemistry, and as a building block for more complex molecules. This research brief aims to synthesize the latest findings on 1,4-Piperazinediethanol, focusing on its synthesis, properties, and emerging applications in biomedicine.
One of the key areas of interest is the role of 1,4-Piperazinediethanol in the development of novel drug delivery systems. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy as a linker in polymer-drug conjugates, enhancing the solubility and bioavailability of hydrophobic therapeutic agents. The study utilized advanced spectroscopic techniques, including NMR and mass spectrometry, to confirm the structural integrity of the synthesized conjugates.
In addition to its pharmaceutical applications, 1,4-Piperazinediethanol has been investigated for its potential in material science. Researchers at MIT recently reported its use in the synthesis of biodegradable polymers with tunable mechanical properties. These polymers exhibit promise for use in medical implants and tissue engineering scaffolds, owing to their biocompatibility and controlled degradation rates.
Another noteworthy development is the exploration of 1,4-Piperazinediethanol as a precursor for the synthesis of antimicrobial agents. A 2024 study in Bioorganic & Medicinal Chemistry Letters revealed that derivatives of this compound exhibit potent activity against multidrug-resistant bacterial strains. The study employed molecular docking simulations to elucidate the binding interactions between the derivatives and bacterial target proteins, providing a foundation for future drug development efforts.
Despite these advancements, challenges remain in optimizing the synthetic routes for 1,4-Piperazinediethanol to improve yield and scalability. Recent work by a team at the University of Cambridge has addressed this issue by developing a greener, one-pot synthesis method that reduces the use of hazardous reagents. This method not only enhances the sustainability of the production process but also aligns with the growing emphasis on green chemistry in pharmaceutical manufacturing.
In conclusion, 1,4-Piperazinediethanol (CAS: 122-96-3) continues to be a compound of significant interest in chemical biology and pharmaceutical research. Its diverse applications, from drug delivery to antimicrobial agents, underscore its potential to address critical challenges in biomedicine. Future research should focus on further elucidating its mechanisms of action and expanding its utility in innovative therapeutic and material science applications.
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