• 1. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 2. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 3. Alt-proteins: A promising future
• 4. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 5. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperazinoazepines Piperazinoazepines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperazinoazepines

Comprehensive Analysis of Mirtazapine-d3 N-Oxide (CAS No. 1219155-54-0): Applications and Research Insights

Mirtazapine-d3 N-Oxide (CAS No. 1219155-54-0) is a deuterated analog of the well-known antidepressant Mirtazapine, specifically designed for advanced pharmacological and analytical research. This compound is increasingly gaining attention due to its role in metabolite studies, drug development, and quantitative mass spectrometry. Researchers and pharmaceutical professionals are leveraging its unique properties to enhance precision in pharmacokinetic analyses and therapeutic monitoring.

The deuterium-labeled structure of Mirtazapine-d3 N-Oxide makes it an invaluable internal standard in LC-MS/MS (Liquid Chromatography-Tandem Mass Spectrometry) applications. With the growing demand for personalized medicine and precision dosing, this compound addresses critical challenges in quantifying Mirtazapine and its metabolites in biological matrices. Its stability and isotopic purity (≥98%) ensure reliable data reproducibility, a key factor in regulatory submissions for drug approval.

Recent trends in neuropharmacology highlight the importance of understanding drug metabolism pathways. Mirtazapine-d3 N-Oxide serves as a reference material for investigating N-oxidation, a common metabolic transformation mediated by hepatic enzymes. This aligns with current industry focus on enzyme kinetics and drug-drug interactions, particularly for psychotropic agents. Studies using this compound have contributed to elucidating mechanisms behind inter-individual variability in drug response.

From a technical perspective, the synthesis of Mirtazapine-d3 N-Oxide involves sophisticated deuterium incorporation techniques to maintain molecular integrity while achieving high isotopic enrichment. Analytical methods such as NMR spectroscopy and high-resolution mass spectrometry are routinely employed for quality verification. These protocols meet the stringent requirements of Good Laboratory Practice (GLP) and ISO 17025 standards, ensuring compliance with global research norms.

The compound’s relevance extends to forensic toxicology, where accurate detection of antidepressant metabolites is crucial for postmortem investigations. With rising public interest in mental health therapeutics and antidepressant safety, Mirtazapine-d3 N-Oxide provides forensic labs with a robust tool for distinguishing between endogenous compounds and administered drugs. This application has been particularly valuable in cases involving polypharmacy or overdose scenarios.

Emerging discussions in pharmacogenomics further underscore the significance of this deuterated standard. Genetic polymorphisms in enzymes like CYP2D6 and CYP3A4 can significantly alter Mirtazapine metabolism. By using Mirtazapine-d3 N-Oxide as a control, researchers can better correlate metabolic ratios with specific genotypes, paving the way for tailored antidepressant therapies. This aligns with the broader healthcare shift toward patient-centric treatment models.

In conclusion, Mirtazapine-d3 N-Oxide (CAS No. 1219155-54-0) represents a critical tool at the intersection of analytical chemistry, clinical research, and therapeutic drug monitoring. Its applications span from basic science to translational medicine, addressing contemporary challenges in psychopharmacology and biomarker discovery. As research methodologies evolve, this compound will continue to play a pivotal role in advancing our understanding of antidepressant pharmacology.

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