Guanidine-15N3 Hydrochloride is a stable isotope-labeled compound where three nitrogen atoms (15N) replace the natural isotopes, enhancing its utility in NMR spectroscopy and mass spectrometry studies. This labeled derivative of guanidine hydrochloride is particularly valuable in metabolic research, protein folding studies, and quantitative proteomics, where precise tracking of nitrogen incorporation is required. Its high isotopic purity ensures minimal interference in experimental results. The compound retains the strong chaotropic properties of guanidine HCl, making it suitable for protein denaturation while enabling isotopic tracing. It is commonly used in biochemical and pharmaceutical research to investigate molecular interactions and pathways with high specificity.