Cas no 1215573-50-4 (4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo3,4-dpyrimidine)

4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine is a heterocyclic compound featuring a pyrazolo[3,4-d]pyrimidine core with a tert-butyl group at the 1-position and a 2-hydroxyphenyl substituent at the 3-position. Its structural complexity and functional groups make it a valuable intermediate in medicinal chemistry, particularly for the synthesis of kinase inhibitors and other biologically active molecules. The amino and hydroxyl groups enhance its reactivity, enabling selective modifications for targeted applications. The tert-butyl moiety contributes to steric stability, improving solubility and metabolic resistance. This compound is suited for research in drug discovery, offering a versatile scaffold for developing novel therapeutic agents.
4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo3,4-dpyrimidine structure
1215573-50-4 structure
Product Name:4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo3,4-dpyrimidine
CAS No:1215573-50-4
MF:C15H17N5O
MW:283.328382253647
CID:1059844
PubChem ID:135431825
Update Time:2025-05-19

4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo3,4-dpyrimidine Chemical and Physical Properties

Names and Identifiers

    • 4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine
    • 2,4-Cyclohexadien-1-one, 6-[4-amino-1-(1,1-dimethylethyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ylidene]-, (6Z)-
    • DB-295105
    • 1215573-50-4
    • J-000780
    • 6-[(3Z)-4-amino-1-tert-butyl-2H-pyrazolo[3,4-d]pyrimidin-3-ylidene]cyclohexa-2,4-dien-1-one
    • 1027572-46-8
    • 2-{4-amino-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl}phenol
    • 2-(4-amino-1-tert-butylpyrazolo[3,4-d]pyrimidin-3-yl)phenol
    • Hydroxy-PP;
    • 4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo3,4-dpyrimidine
    • Inchi： 1S/C15H17N5O/c1-15(2,3)20-14-11(13(16)17-8-18-14)12(19-20)9-6-4-5-7-10(9)21/h4-8,21H,1-3H3,(H2,16,17,18)
    • InChI Key： CPZBAYHPGAUAKO-UHFFFAOYSA-N
    • SMILES： OC1C=CC=CC=1C1C2=C(N)N=CN=C2N(C(C)(C)C)N=1

Computed Properties

  • Exact Mass: 283.14331018g/mol
  • Monoisotopic Mass: 283.14331018g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 21
  • Rotatable Bond Count: 2
  • Complexity: 372
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2
  • Topological Polar Surface Area: 89.8?2

4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo3,4-dpyrimidine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
A602955-5mg
4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine
 1215573-50-4
5mg
 $ 173.00 2023-09-08
TRC
A602955-50mg
4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine
 1215573-50-4
50mg
 $ 1355.00 2023-09-08

4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo3,4-dpyrimidine Related Literature

Additional information on 4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo3,4-dpyrimidine

4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS No. 1215573-50-4): An Emerging Compound in Medicinal Chemistry

4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS No. 1215573-50-4) is a promising compound in the field of medicinal chemistry, particularly in the development of novel therapeutic agents. This compound belongs to the class of pyrazolopyrimidines, which have gained significant attention due to their diverse biological activities and potential applications in various diseases.

The structure of 4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine is characterized by a pyrazolopyrimidine core with specific functional groups that contribute to its unique properties. The presence of the amino group, tert-butyl substituent, and 2-hydroxyphenyl moiety imparts specific pharmacological effects and enhances its bioavailability and stability.

Recent studies have highlighted the potential of 4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine in various therapeutic areas. One of the most notable applications is in the treatment of cancer. Research has shown that this compound exhibits potent antiproliferative activity against several cancer cell lines, including breast, lung, and colon cancer cells. The mechanism of action involves the inhibition of key enzymes involved in cell proliferation and survival pathways.

In addition to its anticancer properties, 4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine has also been investigated for its potential as an anti-inflammatory agent. Studies have demonstrated that this compound can effectively reduce inflammation by inhibiting the production of pro-inflammatory cytokines and mediators. This makes it a potential candidate for the treatment of inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

The pharmacokinetic properties of 4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine have been extensively studied to ensure its suitability for clinical use. Preclinical studies have shown that this compound has favorable absorption, distribution, metabolism, and excretion (ADME) profiles. It exhibits good oral bioavailability and a long half-life, which are crucial factors for its therapeutic efficacy.

To further enhance the therapeutic potential of 4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine, researchers are exploring various drug delivery systems. Nanoparticle-based delivery systems have shown promise in improving the solubility and targeting efficiency of this compound. These delivery systems can potentially reduce side effects and increase the therapeutic index.

Clinical trials are currently underway to evaluate the safety and efficacy of 4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine in human subjects. Early results from phase I trials have been encouraging, with no significant adverse effects reported at therapeutic doses. These findings pave the way for more advanced clinical trials to assess its effectiveness in treating various diseases.

In conclusion, 4-Amino-1-tert-butyl-3-(2-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine (CAS No. 1215573-50-4) is a promising compound with a wide range of potential applications in medicinal chemistry. Its unique structure and pharmacological properties make it a valuable candidate for further research and development. As ongoing studies continue to uncover new insights into its mechanisms of action and therapeutic potential, it is likely that this compound will play a significant role in advancing the treatment options for various diseases.

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