• 1. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 2. An insight into the role of side chains in the microstructure and carrier mobility of high-performance conjugated polymers?
  Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
• 3. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 4. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 5. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonyl compounds Benzenesulfonyl halides

Comprehensive Overview of 4,5-Dichloro-2-methylbenzenesulfonyl Chloride (CAS No. 1215295-88-7): Properties, Applications, and Industry Insights

4,5-Dichloro-2-methylbenzenesulfonyl Chloride (CAS No. 1215295-88-7) is a specialized sulfonyl chloride derivative widely recognized for its role in organic synthesis and pharmaceutical intermediates. This compound, characterized by its dichloro-methyl-substituted benzene ring, exhibits unique reactivity, making it valuable for constructing complex molecular architectures. With the growing demand for high-purity chemical reagents in drug discovery and material science, this compound has garnered significant attention in research and industrial applications.

The molecular structure of 4,5-Dichloro-2-methylbenzenesulfonyl Chloride features a sulfonyl chloride functional group (–SO₂Cl), which serves as a versatile precursor for sulfonamides, sulfonate esters, and other sulfur-containing compounds. Researchers frequently employ it in nucleophilic substitution reactions, leveraging its reactivity with amines or alcohols. Its chloro-methyl substitution pattern further enhances its utility in regioselective transformations, a topic frequently searched in organic chemistry forums and synthetic methodology studies.

In the context of green chemistry trends, the compound’s efficient synthesis and minimal byproduct formation align with the industry’s shift toward sustainable chemical processes. Recent publications highlight its use in catalyzed reactions, where it contributes to atom economy—a key metric in environmentally friendly synthesis. This aligns with frequent search queries such as "eco-friendly sulfonation methods" and "reducing waste in organic synthesis", reflecting user interest in sustainable practices.

From an analytical perspective, 4,5-Dichloro-2-methylbenzenesulfonyl Chloride is typically characterized via NMR spectroscopy (1H and 13C) and mass spectrometry, techniques often discussed in analytical chemistry communities. Its stability under controlled conditions makes it suitable for long-term storage, though precautions like moisture-free environments are recommended—a detail frequently queried in chemical handling guidelines.

The compound’s relevance extends to agrochemical research, where sulfonyl chlorides serve as intermediates for herbicide development. This connection addresses common searches like "sulfonyl chloride applications in agriculture". Additionally, its role in dye synthesis and polymer modification underscores its interdisciplinary importance, bridging gaps between pharmaceutical, material science, and industrial chemistry sectors.

Quality control of CAS No. 1215295-88-7 involves stringent HPLC purity testing and residual solvent analysis, topics trending in QC/QA discussions. Suppliers often highlight batch-to-batch consistency, responding to user concerns about reproducibility in research. Such details are critical for laboratories requiring high-performance building blocks for precision-driven projects.

Emerging studies explore the compound’s potential in bioconjugation chemistry, particularly for modifying biomolecules—a hotspot in drug delivery system research. This aligns with frequent searches on "sulfonyl chlorides in biopharmaceuticals", demonstrating its evolving applications beyond traditional synthetic roles.

In summary, 4,5-Dichloro-2-methylbenzenesulfonyl Chloride (CAS No. 1215295-88-7) represents a multifaceted tool for modern chemistry, addressing needs from small-molecule synthesis to advanced material engineering. Its intersection with sustainability, analytical innovation, and cross-industry utility ensures its continued relevance in scientific and industrial advancements.

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