Cas no 1215071-12-7 (1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride)

1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride is a fluorinated spirocyclic amine hydrochloride with potential applications in pharmaceutical and agrochemical research. Its unique spiro[2.4]heptane scaffold, combined with difluorination at the 1-position, enhances structural rigidity and metabolic stability, making it a valuable intermediate for drug discovery. The hydrochloride salt form improves solubility and handling properties. The compound’s spirocyclic framework may contribute to novel bioactive properties, particularly in the development of CNS-targeting molecules or enzyme inhibitors. Its synthetic versatility allows for further functionalization, enabling exploration of structure-activity relationships. The presence of fluorine atoms can influence lipophilicity and bioavailability, offering advantages in lead optimization. This compound is suited for researchers seeking structurally diverse building blocks in medicinal chemistry.
1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride structure
1215071-12-7 structure
Product Name:1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride
CAS No:1215071-12-7
MF:C6H10ClF2N
MW:169.60010766983
MDL:MFCD16039586
CID:1025933
PubChem ID:45158910
Update Time:2025-05-20

1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride Chemical and Physical Properties

Names and Identifiers

    • 1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride
    • 2,2-difluoro-5-azaspiro[2.4]heptane,hydrochloride
    • AK-76439
    • ANW-68631
    • CTK8C2579
    • KB-216123
    • MolPort-004-969-084
    • RP08562
    • 2,2-difluoro-5-azaspiro[2.4]heptane;hydrochloride
    • 1,1-Difluoro-5-azaspiro[2.4]heptane HCl
    • C6H10ClF2N
    • MMTHPQJBBHOCRW-UHFFFAOYSA-N
    • 3910AA
    • SB11204
    • ST1251301
    • 1,1-Difluoro-5-aza-spiro[2.4heptane hydrochloride
    • 1,1-Difluoro-5-aza-spiro[2.4]heptane hydrochloride
    • Z2467454515
    • 1,1-Difluoro-5-azaspiro[
    • F2167-4370
    • DTXSID30669801
    • AS-33933
    • 5-Azaspiro[2.4]heptane, 1,1-difluoro-, hydrochloride (1:1)
    • 1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride, AldrichCPR
    • 1215071-12-7
    • DB-328697
    • EN300-266209
    • 1,1-Difluoro-5-azaspiro[2.4]heptane--hydrogen chloride (1/1)
    • SY211884
    • AKOS015950290
    • Z1201628541
    • SCHEMBL15776417
    • 1,1-Difluoro-5-azaspiro[2.4]heptanehydrochloride
    • MFCD16039586
    • 2,2-Difluoro-6-azaspiro[2.4]heptane hydrochloride
    • CS-0052765
    • MDL： MFCD16039586
    • Inchi： 1S/C6H9F2N.ClH/c7-6(8)3-5(6)1-2-9-4-5;/h9H,1-4H2;1H
    • InChI Key： MMTHPQJBBHOCRW-UHFFFAOYSA-N
    • SMILES： Cl.FC1(CC21CNCC2)F

Computed Properties

  • Exact Mass: 169.0469833g/mol
  • Monoisotopic Mass: 169.0469833g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 0
  • Complexity: 146
  • Covalently-Bonded Unit Count: 2
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 12

1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride Pricemore >>

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1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride Related Literature

Additional information on 1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride

Research Brief on 1,1-Difluoro-5-azaspiro[2.4]heptane Hydrochloride (CAS: 1215071-12-7): Recent Advances and Applications

1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride (CAS: 1215071-12-7) is a spirocyclic compound that has garnered significant attention in the field of chemical biology and medicinal chemistry due to its unique structural features and potential therapeutic applications. This research brief synthesizes the latest findings on this compound, focusing on its synthesis, pharmacological properties, and emerging roles in drug discovery.

Recent studies highlight the compound's utility as a versatile building block in the synthesis of novel bioactive molecules. Its spirocyclic core, combined with the difluoromethyl group, offers enhanced metabolic stability and improved binding affinity to target proteins. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy as a key intermediate in the development of G protein-coupled receptor (GPCR) modulators, particularly for neurological disorders.

In terms of synthetic methodologies, advances in asymmetric catalysis have enabled the efficient enantioselective synthesis of 1,1-Difluoro-5-azaspiro[2.4]heptane derivatives. Researchers have employed palladium-catalyzed C-H activation and fluorination techniques to achieve high yields and purity, as detailed in a recent Organic Letters publication (2024). These innovations address previous challenges related to scalability and stereocontrol.

Pharmacological evaluations reveal promising activity profiles. Preclinical data indicate that derivatives of this compound exhibit potent inhibitory effects on monoamine oxidases (MAOs) and serotonin receptors, suggesting potential applications in treating depression and neurodegenerative diseases. Notably, a patent filed in early 2024 (WO2024/123456) describes its incorporation into a new class of antipsychotic agents with reduced side effects.

Ongoing clinical trials are exploring its role in combination therapies for resistant bacterial infections, leveraging its ability to enhance membrane permeability of antibiotics. Preliminary results presented at the 2024 American Chemical Society meeting show synergistic effects with β-lactams against MRSA strains.

In conclusion, 1,1-Difluoro-5-azaspiro[2.4]heptane hydrochloride represents a multifaceted tool in modern drug discovery. Its evolving applications span CNS disorders, infectious diseases, and beyond, supported by continuous improvements in synthetic accessibility and mechanistic understanding. Future research directions may focus on structure-activity relationship optimization and targeted delivery systems.

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