• 1. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 2. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 3. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 4. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 5. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084

Comprehensive Overview of 4-Chloro-3,5-di(pyridin-3-yl)pyridine (CAS No. 1214354-34-3): Properties, Applications, and Research Insights

4-Chloro-3,5-di(pyridin-3-yl)pyridine (CAS No. 1214354-34-3) is a heterocyclic organic compound that has garnered significant attention in pharmaceutical and materials science research. This compound, characterized by its unique pyridine-based structure, serves as a versatile intermediate in the synthesis of complex molecules. Its molecular formula, chemical properties, and synthetic applications make it a subject of interest for researchers exploring drug discovery, catalysis, and advanced materials.

The compound’s structure features two pyridin-3-yl groups attached to a central pyridine ring, with a chlorine atom at the 4-position. This arrangement contributes to its electron-rich nature, enabling interactions with various biological targets and metal ions. Recent studies highlight its potential in designing kinase inhibitors, a hot topic in cancer research, as well as its role in ligand design for transition-metal catalysts. These applications align with growing user searches for "pyridine derivatives in medicine" and "heterocyclic compounds in catalysis."

From a synthetic chemistry perspective, 4-Chloro-3,5-di(pyridin-3-yl)pyridine is often synthesized via cross-coupling reactions, such as Suzuki-Miyaura or Stille couplings, which are frequently searched by organic chemists. Its solubility in polar solvents like DMSO and methanol further enhances its utility in high-throughput screening and medicinal chemistry workflows. Researchers also investigate its photophysical properties, linking it to trends in organic electronics and light-emitting materials—a niche with rising interest due to advancements in OLED technology.

In the context of drug development, this compound’s bioavailability and metabolic stability are critical factors. Computational studies using molecular docking and QSAR modeling (frequently queried in AI-driven research) suggest its potential as a scaffold for central nervous system (CNS) therapeutics. This aligns with popular search terms like "pyridine-based CNS drugs" and "small molecule neuro modulators." Additionally, its low toxicity profile in preliminary assays makes it a candidate for further preclinical evaluation.

Beyond pharmaceuticals, CAS No. 1214354-34-3 finds relevance in coordination chemistry. Its ability to act as a multidentate ligand for metals like palladium and ruthenium supports applications in homogeneous catalysis, a field trending due to sustainable chemistry initiatives. Users often search for "N-donor ligands in catalysis" or "pyridine-metal complexes," reflecting this demand. Recent patents also highlight its use in polymer stabilization and corrosion inhibition, addressing industrial pain points.

To summarize, 4-Chloro-3,5-di(pyridin-3-yl)pyridine exemplifies the intersection of academic research and industrial innovation. Its multifaceted roles—from drug design to material science—resonate with current scientific trends and user inquiries. As interest grows in tailored heterocycles and green chemistry, this compound’s synthetic adaptability and functional diversity position it as a key player in future breakthroughs.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)