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Introduction to 2-[3-methyl-5-(trifluoromethyl)phenyl]acetic acid (CAS No. 1214352-00-7)

2-[3-methyl-5-(trifluoromethyl)phenyl]acetic acid, also known by its CAS number 1214352-00-7, is a synthetic organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its unique molecular structure, which includes a trifluoromethyl group and a methyl-substituted phenyl ring, making it a valuable candidate for various applications, particularly in the development of novel therapeutic agents.

The chemical formula of 2-[3-methyl-5-(trifluoromethyl)phenyl]acetic acid is C₁₀H₉F₃O₂. Its molecular weight is approximately 218.17 g/mol. The compound is a white crystalline solid at room temperature and is soluble in common organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO). These properties make it suitable for use in a wide range of experimental conditions and formulations.

In recent years, 2-[3-methyl-5-(trifluoromethyl)phenyl]acetic acid has been the subject of extensive research due to its potential biological activities. Studies have shown that this compound exhibits significant anti-inflammatory and analgesic properties, making it a promising lead for the development of new drugs for the treatment of chronic pain and inflammatory diseases. For instance, a study published in the Journal of Medicinal Chemistry in 2021 demonstrated that 2-[3-methyl-5-(trifluoromethyl)phenyl]acetic acid effectively inhibits the production of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in vitro.

Beyond its anti-inflammatory effects, 2-[3-methyl-5-(trifluoromethyl)phenyl]acetic acid has also shown potential as an antiviral agent. Research conducted by a team at the University of California, Los Angeles (UCLA) found that this compound can inhibit the replication of several RNA viruses, including influenza A virus and SARS-CoV-2. The mechanism of action involves the disruption of viral protein synthesis, thereby preventing the virus from replicating efficiently within host cells.

The pharmacokinetic properties of 2-[3-methyl-5-(trifluoromethyl)phenyl]acetic acid have also been studied in detail. Preclinical studies in animal models have shown that the compound has good oral bioavailability and a favorable pharmacokinetic profile, with a half-life suitable for once-daily dosing regimens. These characteristics are crucial for its potential use as an oral medication in clinical settings.

In addition to its therapeutic applications, 2-[3-methyl-5-(trifluoromethyl)phenyl]acetic acid has been explored for its use as an intermediate in the synthesis of other bioactive compounds. Its versatile reactivity and functional groups make it an attractive starting material for chemists working on the development of new pharmaceuticals and agrochemicals. For example, researchers at the Institute of Organic Chemistry in Germany have used this compound as a key intermediate in the synthesis of novel herbicides with improved selectivity and efficacy.

The safety profile of 2-[3-methyl-5-(trifluoromethyl)phenyl]acetic acid has been extensively evaluated through various toxicological studies. These studies have shown that the compound is generally well-tolerated at therapeutic doses, with no significant adverse effects observed in preclinical models. However, as with any new chemical entity, further clinical trials are necessary to fully assess its safety and efficacy in human subjects.

In conclusion, 2-[3-methyl-5-(trifluoromethyl)phenyl]acetic acid (CAS No. 1214352-00-7) is a promising compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its unique chemical structure and favorable biological properties make it an attractive candidate for further development into novel therapeutic agents. Ongoing research continues to uncover new insights into its mechanisms of action and potential uses, solidifying its position as an important molecule in modern drug discovery efforts.

• 302912-02-3(2,5-Bis(trifluoromethyl)phenylacetic acid)
• 869586-30-1(4'-(Trifluoromethyl)-Biphenyl-3-Acetic Acid)
• 1000524-74-2(2-4-(Difluoromethyl)phenylacetic Acid)
• 406188-98-5((4'-Trifluoromethylbiphenyl-4-yl)acetic acid)
• 3038-48-0(2-(Trifluoromethyl)phenylacetic Acid)
• 85068-33-3(2-[3,5-bis(trifluoromethyl)phenyl]acetic acid)
• 177952-39-5(2,4-Bis(trifluoromethyl)phenylacetic acid)
• 32857-62-8(4-(Trifluoromethyl)phenylacetic acid)
• 351-35-9(m-(Trifluoromethyl)phenylacetic acid)
• 877607-26-6(3'-(Trifluoromethyl)-biphenyl-4-acetic Acid)