• 1. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 2. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151
• 3. Distribution and ecological risk assessment of typical antibiotics in the surface waters of seven major rivers, China?
  Environ. Sci.: Processes Impacts, 2021,23, 1088-1100
• 4. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 5. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555

Introduction to 2,5-Dichloro-4-fluoropyridine (CAS No. 1214350-63-6)

2,5-Dichloro-4-fluoropyridine, with the chemical formula C?H?Cl?FN?, is a fluorinated pyridine derivative that has garnered significant attention in the field of pharmaceutical and agrochemical research. This compound, identified by its CAS number 1214350-63-6, serves as a crucial intermediate in the synthesis of various biologically active molecules. Its unique structural features—comprising chlorine and fluorine substituents at specific positions—make it a versatile building block for drug discovery programs.

The significance of 2,5-Dichloro-4-fluoropyridine lies in its ability to undergo diverse chemical transformations, enabling the construction of complex heterocyclic scaffolds. These transformations are particularly valuable in medicinal chemistry, where the introduction of fluorine atoms is often employed to enhance metabolic stability, binding affinity, and overall pharmacological activity. The presence of two chlorine atoms at the 2- and 5-positions further expands its synthetic utility, allowing for selective functionalization and derivatization.

In recent years, 2,5-Dichloro-4-fluoropyridine has been extensively explored in the development of novel therapeutic agents. One notable area of research involves its application in the synthesis of kinase inhibitors, which are critical in treating cancers and inflammatory diseases. The pyridine core is a common motif in many kinase inhibitors due to its ability to mimic ATP binding pockets. By incorporating fluorine and chlorine atoms strategically, researchers can fine-tune the electronic properties and steric interactions of these inhibitors, leading to improved efficacy.

Moreover, 2,5-Dichloro-4-fluoropyridine has found utility in the creation of antimicrobial agents. The increasing prevalence of drug-resistant pathogens has driven the search for new chemical entities with broad-spectrum activity. Fluorinated pyridines have demonstrated promise in this regard, as their structural features can disrupt bacterial cell wall synthesis or interfere with essential metabolic pathways. Studies have shown that derivatives of 2,5-Dichloro-4-fluoropyridine exhibit potent activity against Gram-positive and Gram-negative bacteria, making them attractive candidates for further development.

The agrochemical sector has also benefited from the use of 2,5-Dichloro-4-fluoropyridine as an intermediate. Pyridine-based compounds are widely employed in pesticides and herbicides due to their ability to interact with biological targets in plants and pests. The incorporation of fluorine and chlorine substituents enhances the bioactivity and environmental stability of these agrochemicals. Recent research highlights the development of novel herbicides derived from 2,5-Dichloro-4-fluoropyridine, which exhibit improved selectivity and reduced environmental impact compared to traditional formulations.

From a synthetic chemistry perspective, 2,5-Dichloro-4-fluoropyridine offers several advantages as a starting material. Its reactivity allows for facile introduction of additional functional groups via nucleophilic aromatic substitution (SNAr), cross-coupling reactions (e.g., Suzuki-Miyaura), and metal-catalyzed transformations. These reactions are well-documented in organic synthesis literature and have been leveraged to produce a wide array of derivatives with tailored properties. The compound's stability under various reaction conditions further underscores its value as a synthetic intermediate.

The pharmaceutical industry's interest in fluorinated pyridines is not without precedent. Many FDA-approved drugs contain pyridine moieties with fluorine substituents, demonstrating their importance in drug design. For instance, fluoroquinolones—a class of antibiotics—utilize fluorinated pyridines as key structural components. The success of these drugs has spurred further investigation into fluorinated pyridines as pharmacophores, with 2,5-Dichloro-4-fluoropyridine being a prime example of a compound with high synthetic potential.

In conclusion,2,5-Dichloro-4-fluoropyridine (CAS No. 1214350-63-6) is a multifaceted compound with significant applications across pharmaceuticals and agrochemicals. Its unique structural features enable diverse chemical transformations that are critical for drug discovery and development. As research continues to uncover new biological targets and synthetic methodologies,2,5-Dichloro-4-fluoropyridine will undoubtedly remain at the forefront of molecular innovation.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)