Cas no 1214349-71-9 (5-Chloro-3-(trifluoromethyl)picolinonitrile)
5-Chloro-3-(trifluoromethyl)picolinonitrile is a versatile heterocyclic compound featuring a chloro-substituted pyridine core with a trifluoromethyl group and a nitrile functionality at the 3-position. Its unique structure makes it a valuable intermediate in pharmaceutical and agrochemical synthesis, particularly in the development of active ingredients requiring enhanced metabolic stability and lipophilicity. The presence of both electron-withdrawing groups (chloro and trifluoromethyl) and the nitrile moiety allows for selective reactivity in cross-coupling and nucleophilic substitution reactions. This compound is particularly useful in the preparation of biologically active molecules, offering precise control over molecular properties for targeted applications. Its high purity and stability further ensure reliable performance in synthetic workflows.
1214349-71-9 structure
Product Name:5-Chloro-3-(trifluoromethyl)picolinonitrile
CAS No:1214349-71-9
MF:C7H2ClF3N2
MW:206.552390575409
MDL:MFCD13185435
CID:1037469
PubChem ID:70412037
Update Time:2025-10-24
5-Chloro-3-(trifluoromethyl)picolinonitrile Chemical and Physical Properties
Names and Identifiers
-
- 5-Chloro-3-(trifluoromethyl)picolinonitrile
- 5-chloro-3-(trifluoromethyl)-2-Pyridinecarbonitrile
- CS-0136662
- MFCD13185435
- 2-Pyridinecarbonitrile, 5-chloro-3-(trifluoromethyl)-
- 5-Chloro-3-(trifluoromethyl)pyridine-2-carbonitrile
- F10576
- SCHEMBL10647301
- 5-chloro-2-cyano-3-(trifluoromethyl)pyridine
- AKOS016009101
- SY244168
- AMY17001
- 1214349-71-9
- DB-061907
- DTXSID20741928
- DS-4373
- LMNDQHSGIICWCP-UHFFFAOYSA-N
- 5-Chloro-3-trifluoromethyl-pyridine-2-carbonitrile
-
- MDL： MFCD13185435
- Inchi： 1S/C7H2ClF3N2/c8-4-1-5(7(9,10)11)6(2-12)13-3-4/h1,3H
- InChI Key： LMNDQHSGIICWCP-UHFFFAOYSA-N
- SMILES： ClC1=CN=C(C#N)C(C(F)(F)F)=C1
Computed Properties
- Exact Mass: 205.9858603g/mol
- Monoisotopic Mass: 205.9858603g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 13
- Rotatable Bond Count: 1
- Complexity: 232
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 2.4
- Topological Polar Surface Area: 36.7?2
Experimental Properties
- Density: 1.51
- Boiling Point: 241 oC
- Flash Point: 99 oC
5-Chloro-3-(trifluoromethyl)picolinonitrile Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Alichem | A026002339-1g |
5-Chloro-2-cyano-3-(trifluoromethyl)pyridine |
1214349-71-9 | 97% | 1g |
$1286.49 | 2023-09-04 | |
| Chemenu | CM173748-1g |
5-Chloro-2-cyano-3-(trifluoromethyl)pyridine |
1214349-71-9 | 95% | 1g |
$795 | 2021-08-05 | |
| abcr | AB512524-250 mg |
5-Chloro-3-(trifluoromethyl)picolinonitrile; . |
1214349-71-9 | 250MG |
€777.80 | 2023-04-18 | ||
| eNovation Chemicals LLC | Y1197864-1g |
5-Chloro-3-(trifluoromethyl)pyridine-2-carbonitrile |
1214349-71-9 | 95% | 1g |
$1045 | 2024-07-20 | |
| Chemenu | CM173748-1g |
5-Chloro-2-cyano-3-(trifluoromethyl)pyridine |
1214349-71-9 | 95% | 1g |
$795 | 2022-06-14 | |
| eNovation Chemicals LLC | Y0978447-1g |
5-chloro-3-(trifluoromethyl)picolinonitrile |
1214349-71-9 | 95% | 1g |
$270 | 2024-08-02 | |
| abcr | AB512524-100 mg |
5-Chloro-3-(trifluoromethyl)picolinonitrile; . |
1214349-71-9 | 100MG |
€418.20 | 2023-04-18 | ||
| abcr | AB512524-250mg |
5-Chloro-3-(trifluoromethyl)picolinonitrile; . |
1214349-71-9 | 250mg |
€242.20 | 2025-04-22 | ||
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBTF974-100mg |
5-chloro-3-(trifluoromethyl)pyridine-2-carbonitrile |
1214349-71-9 | 97% | 100mg |
￥371.0 | 2024-04-25 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBTF974-250mg |
5-chloro-3-(trifluoromethyl)pyridine-2-carbonitrile |
1214349-71-9 | 97% | 250mg |
￥741.0 | 2024-04-25 |
5-Chloro-3-(trifluoromethyl)picolinonitrile Related Literature
-
Ravi Kumar Yadav,R. Govindaraj Phys. Chem. Chem. Phys., 2020,22, 26876-26886
-
2. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
-
Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
-
Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
-
Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
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