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  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
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  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
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  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
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  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Aralkylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Aralkylamines

Comprehensive Overview of (1R)-1-(5-fluoro-3-pyridyl)ethanamine (CAS No. 1212854-34-6): Properties, Applications, and Industry Insights

(1R)-1-(5-fluoro-3-pyridyl)ethanamine, with the CAS number 1212854-34-6, is a chiral amine derivative featuring a fluorinated pyridine moiety. This compound has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural properties and potential as a building block for bioactive molecules. The presence of both a fluoro substituent and a stereogenic center (1R configuration) makes it a valuable intermediate for designing targeted therapies and specialty chemicals.

In recent years, the demand for fluorinated pyridine derivatives like (1R)-1-(5-fluoro-3-pyridyl)ethanamine has surged, driven by trends in drug discovery and sustainable chemistry. Researchers frequently search for "chiral amine synthesis," "fluoro-pyridine applications," or "CAS 1212854-34-6 supplier," reflecting its commercial and scientific relevance. The compound’s high purity grade (>98%) and stability under controlled conditions further enhance its utility in asymmetric catalysis and API development.

From a synthetic perspective, (1R)-1-(5-fluoro-3-pyridyl)ethanamine is often prepared via enantioselective reduction of corresponding imines or through resolution techniques. Its molecular formula C7H9FN2 and molecular weight 140.16 g/mol are critical for stoichiometric calculations in multi-step reactions. Analytical methods such as HPLC, NMR, and mass spectrometry are routinely employed to verify its identity and enantiomeric excess (ee), addressing common queries like "how to characterize chiral amines" or "1212854-34-6 analytical data."

The compound’s applications span multiple domains. In pharmaceuticals, it serves as a precursor for neurological agents and kinase inhibitors, aligning with industry interest in "small molecule drug candidates." Its ligand properties also make it useful in metal-organic frameworks (MOFs) for catalysis—a hot topic in green chemistry discussions. Notably, patents referencing CAS 1212854-34-6 highlight its role in optimizing bioavailability and metabolic stability of lead compounds.

Regulatory and safety profiles of (1R)-1-(5-fluoro-3-pyridyl)ethanamine adhere to standard laboratory handling protocols. While not classified as hazardous under GHS, proper storage in anhydrous conditions at 2–8°C is recommended to preserve its integrity. This aligns with frequently searched terms such as "amine storage guidelines" and "fluoropyridine stability." Suppliers often provide technical datasheets and COA (Certificate of Analysis) to ensure compliance with research and industrial standards.

Emerging trends in AI-driven molecular design and high-throughput screening have further amplified interest in this compound. Computational studies leveraging QSAR models frequently incorporate 1212854-34-6 as a reference structure for ADMET prediction. Such applications resonate with searches like "machine learning in chemical synthesis" or "predicting amine reactivity," underscoring its interdisciplinary relevance.

In conclusion, (1R)-1-(5-fluoro-3-pyridyl)ethanamine (CAS 1212854-34-6) exemplifies the convergence of chirality, fluorination, and functional group versatility in modern chemistry. Its expanding role in life sciences and material innovation ensures sustained demand, while ongoing research continues to uncover novel applications—making it a compound worth monitoring in scientific and industrial landscapes.

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