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Comprehensive Analysis of 4-Hydroxy-1H-indole-7-carboxamide (CAS No. 1211594-40-9): Properties, Applications, and Research Insights

4-Hydroxy-1H-indole-7-carboxamide (CAS No. 1211594-40-9) is a specialized organic compound belonging to the indole derivatives family, a class of heterocyclic structures widely studied for their diverse biological and pharmacological activities. This compound features a hydroxyl group at the 4-position and a carboxamide moiety at the 7-position of the indole scaffold, making it a promising candidate for medicinal chemistry and drug discovery. Its molecular formula is C₉H₈N₂O₂, with a molecular weight of 176.17 g/mol. Researchers have shown growing interest in this compound due to its potential applications in neurodegenerative disease research, anti-inflammatory agents, and enzyme inhibition studies.

The synthesis of 4-Hydroxy-1H-indole-7-carboxamide typically involves multi-step organic reactions, including Fischer indole synthesis or Palladium-catalyzed coupling, followed by selective functionalization. Its crystalline structure and solubility profile (moderate in polar solvents like DMSO and methanol) make it suitable for in vitro assays and structure-activity relationship (SAR) studies. Recent publications highlight its role as a precursor for designing novel kinase inhibitors, particularly in oncology research, where indole derivatives are explored for their anti-proliferative effects.

In the context of current scientific trends, 1211594-40-9 aligns with the rising demand for small-molecule modulators targeting protein-protein interactions (PPIs). Its hydrogen-bonding capacity (via hydroxyl and carboxamide groups) enables selective binding to biological targets, a feature highly sought after in fragment-based drug design. Notably, indole cores are frequently investigated for GPCR modulation, a hot topic in central nervous system (CNS) drug development.

From an industrial perspective, 4-Hydroxy-1H-indole-7-carboxamide is primarily utilized by pharmaceutical R&D laboratories and academic institutions. Its stability under standard storage conditions (recommended at -20°C in inert atmospheres) ensures reliable performance in high-throughput screening (HTS) platforms. Analytical characterization via HPLC, LC-MS, and NMR spectroscopy confirms its high purity (>95%), a critical parameter for reproducible biological testing.

Environmental and safety assessments indicate that this compound requires standard laboratory handling precautions (use of gloves and eye protection). It is not classified as a hazardous substance under major regulatory frameworks like REACH or OSHA, though proper waste disposal protocols should be followed. Researchers frequently search for "buy 4-Hydroxy-1H-indole-7-carboxamide" or "1211594-40-9 supplier," emphasizing the need for reliable chemical sourcing with certificates of analysis (CoA).

Emerging applications include its evaluation in metabolic disorder models, where indole derivatives show promise in AMPK pathway modulation—a trending area linked to diabetes and obesity research. Additionally, computational studies (molecular docking and QSAR modeling) predict its affinity for serotonin receptors, sparking interest in mood disorder therapeutics.

In summary, CAS 1211594-40-9 represents a versatile research chemical with untapped potential across multiple disciplines. Its structural features align with modern drug discovery paradigms, particularly in targeted therapy development. As the scientific community continues to explore indole-based pharmacophores, this compound is poised to gain further attention in peer-reviewed studies and patent applications.

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