• 1. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 2. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 3. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 4. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

4-Bromo-2-Chloro-3-(Trifluoromethyl)Pyridine: A Comprehensive Overview

The compound 4-bromo-2-chloro-3-(trifluoromethyl)pyridine (CAS No. 1211589-92-2) is a highly specialized aromatic heterocyclic compound with significant applications in various fields, including pharmaceuticals, agrochemicals, and materials science. This compound is characterized by its unique substitution pattern on the pyridine ring, which imparts distinctive chemical and physical properties. The presence of bromine, chlorine, and trifluoromethyl groups at specific positions on the pyridine ring makes it a versatile building block for synthesizing advanced chemical compounds.

Recent studies have highlighted the importance of 4-bromo-2-chloro-3-(trifluoromethyl)pyridine in the development of novel bioactive molecules. For instance, researchers have explored its role as an intermediate in the synthesis of pyridine-based herbicides and insecticides. The trifluoromethyl group, known for its electron-withdrawing properties, enhances the stability and reactivity of the molecule, making it an ideal candidate for various organic transformations.

One of the most notable applications of this compound is in the field of medicinal chemistry. Scientists have utilized 4-bromo-2-chloro-3-(trifluoromethyl)pyridine as a key intermediate in the synthesis of potential anticancer agents. The bromine and chlorine substituents provide sites for further functionalization, enabling the creation of molecules with enhanced bioavailability and selectivity. Recent advancements in click chemistry have further expanded its utility in drug discovery programs.

In addition to its role in pharmaceuticals, 4-bromo-2-chloro-3-(trifluoromethyl)pyridine has gained attention in materials science due to its ability to form stable coordination complexes. These complexes exhibit unique electronic and optical properties, making them promising candidates for applications in organic electronics and optoelectronics. Researchers have also investigated its potential as a precursor for synthesizing advanced materials such as graphene-like structures and metal-organic frameworks (MOFs).

The synthesis of 4-bromo-2-chloro-3-(trifluoromethyl)pyridine involves a multi-step process that typically starts with a pyridine derivative as the parent structure. The introduction of substituents at specific positions requires precise control over reaction conditions to ensure high yields and purity. Recent advancements in catalytic methods have enabled more efficient syntheses, reducing production costs and improving scalability.

From an environmental perspective, understanding the fate and transport of 4-bromo-2-chloro-3-(trifluoromethyl)pyridine in natural systems is crucial for assessing its potential impact on ecosystems. Studies have shown that this compound exhibits moderate biodegradability under aerobic conditions, with microbial communities playing a significant role in its transformation. However, further research is needed to evaluate its long-term persistence and toxicity to aquatic organisms.

In conclusion, 4-bromo-2-chloro-3-(trifluoromethyl)pyridine (CAS No. 1211589-92-2) is a versatile compound with diverse applications across multiple disciplines. Its unique substitution pattern and reactivity make it an invaluable tool for chemists working on innovative solutions in drug discovery, agrochemicals, and materials science. As research continues to uncover new insights into its properties and potential uses, this compound is poised to play an even greater role in advancing modern chemistry.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)