• 1. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
• 2. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 3. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
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• 4. An automatic determination of thoria in thoria-urania mixtures
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• 5. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

Research Brief on 5-Amino-2-methoxy-3-(trifluoromethyl)pyridine (CAS: 1211584-76-7): Recent Advances and Applications

5-Amino-2-methoxy-3-(trifluoromethyl)pyridine (CAS: 1211584-76-7) is a fluorinated pyridine derivative that has garnered significant attention in the field of chemical biology and pharmaceutical research due to its unique structural and electronic properties. This compound serves as a versatile building block in medicinal chemistry, particularly in the synthesis of novel drug candidates targeting various diseases. Recent studies have explored its applications in kinase inhibitors, agrochemicals, and other biologically active molecules, leveraging its trifluoromethyl group for enhanced metabolic stability and binding affinity.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers utilized 5-Amino-2-methoxy-3-(trifluoromethyl)pyridine as a key intermediate in the development of selective JAK2 inhibitors. The trifluoromethyl group was found to significantly improve the pharmacokinetic profile of the inhibitors, demonstrating enhanced oral bioavailability and reduced off-target effects. The study highlighted the compound's role in optimizing drug-like properties, making it a valuable scaffold for kinase-targeted therapies.

Another notable application of this compound was reported in the field of agrochemicals. A 2022 study in Pest Management Science demonstrated its incorporation into novel fungicides, where the electron-withdrawing trifluoromethyl group contributed to increased stability and efficacy against resistant fungal strains. The research underscored the potential of 5-Amino-2-methoxy-3-(trifluoromethyl)pyridine in addressing global challenges in crop protection.

Recent synthetic methodologies have also focused on improving the accessibility of this compound. A 2023 paper in Organic Letters described a scalable, one-pot synthesis route for 5-Amino-2-methoxy-3-(trifluoromethyl)pyridine, reducing production costs and environmental impact. This advancement is expected to facilitate its broader adoption in industrial and academic settings.

In conclusion, 5-Amino-2-methoxy-3-(trifluoromethyl)pyridine (CAS: 1211584-76-7) continues to be a molecule of high interest due to its multifaceted applications in drug discovery and agrochemical development. Ongoing research is likely to uncover additional therapeutic and industrial uses, further solidifying its importance in the chemical biology and pharmaceutical industries.

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