• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 5. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

3-Formylpyridine-4-carbonitrile (CAS No. 1211582-43-2): A Versatile Building Block in Organic Synthesis

3-Formylpyridine-4-carbonitrile (CAS No. 1211582-43-2) is a highly valuable heterocyclic compound that has gained significant attention in the field of organic chemistry and pharmaceutical research. This compound, characterized by its formyl group and nitrile functionality, serves as a crucial intermediate in the synthesis of various bioactive molecules, agrochemicals, and materials. Its unique structural features make it an ideal candidate for multicomponent reactions and cascade transformations, which are currently trending topics in synthetic chemistry.

The growing interest in 3-formylpyridine-4-carbonitrile derivatives can be attributed to their wide range of applications in medicinal chemistry. Researchers are increasingly exploring this compound for the development of kinase inhibitors and antimicrobial agents, addressing the global need for novel therapeutic solutions. Recent studies have highlighted its potential in creating anticancer scaffolds, particularly in the design of targeted therapies that minimize side effects - a hot topic in current pharmaceutical research.

From a synthetic perspective, 3-formylpyridine-4-carbonitrile offers remarkable versatility. Its electron-deficient pyridine ring facilitates various nucleophilic substitution reactions, while the formyl group participates in condensation reactions to form Schiff bases and other valuable intermediates. These properties align perfectly with the current focus on atom-economical synthesis and green chemistry principles, making it a popular choice among researchers developing sustainable synthetic methodologies.

The compound's nitrile group provides additional synthetic handles, allowing for transformations into amides, carboxylic acids, and tetrazoles. This multifunctionality has made 3-formylpyridine-4-carbonitrile particularly valuable in drug discovery programs, where rapid generation of molecular diversity is essential. Recent publications in high-impact journals have demonstrated its utility in constructing privileged scaffolds for various therapeutic targets.

In material science applications, 3-formylpyridine-4-carbonitrile has shown promise as a precursor for functionalized polymers and coordination complexes. Its ability to form stable complexes with transition metals has been exploited in the development of catalytic systems and luminescent materials. These applications are particularly relevant given the current emphasis on energy-efficient technologies and smart materials in industrial research.

The commercial availability of 3-formylpyridine-4-carbonitrile (CAS 1211582-43-2) has increased significantly in recent years, reflecting its growing importance in chemical research. Suppliers now offer various grades of this compound, from research quantities to bulk scale, catering to different application needs. Quality control parameters typically include HPLC purity and spectroscopic characterization, ensuring consistency across batches.

From a safety perspective, proper handling of 3-formylpyridine-4-carbonitrile requires standard laboratory precautions. While not classified as highly hazardous, its nitrile functionality warrants appropriate protective measures during manipulation. Storage recommendations typically suggest cool, dry conditions in tightly sealed containers to maintain stability over extended periods.

The future outlook for 3-formylpyridine-4-carbonitrile applications appears promising, with ongoing research exploring its potential in bioconjugation chemistry and click chemistry applications. Its compatibility with various bioorthogonal reactions makes it particularly attractive for chemical biology studies, a field experiencing rapid growth. Additionally, its use in covalent inhibitor design represents another exciting frontier in drug discovery.

For researchers considering 3-formylpyridine-4-carbonitrile synthesis, several efficient routes have been reported in the literature. These methods typically involve Vilsmeier-Haack formylation of appropriate pyridine precursors or oxidative transformations of corresponding alcohols. The choice of synthetic pathway often depends on the desired scale and available starting materials.

In conclusion, 3-formylpyridine-4-carbonitrile (CAS 1211582-43-2) stands as a remarkably versatile building block with applications spanning pharmaceutical development, material science, and catalysis. Its unique combination of functional groups and synthetic accessibility continues to inspire innovative applications across multiple disciplines. As research progresses, we can anticipate even more creative uses for this valuable compound in addressing contemporary scientific challenges.

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