• 1. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 2. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 3. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 4. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 5. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291

2-Amino-1-(Pyrimidin-5-Yl)Ethan-1-One: A Comprehensive Overview

2-Amino-1-(pyrimidin-5-yl)ethan-1-one, also known by its CAS registry number CAS No. 1211530-06-1, is a heterocyclic organic compound with significant potential in the field of medicinal chemistry. This compound belongs to the class of pyrimidine derivatives, which have been extensively studied for their diverse biological activities, including anti-cancer, anti-inflammatory, and anti-viral properties. The structure of this compound consists of a pyrimidine ring fused with an amino ketone moiety, making it a versatile scaffold for further chemical modifications and functionalization.

Recent advancements in synthetic chemistry have enabled the efficient synthesis of 2-amino-pyrimidine derivatives, including 2-amino-1-(pyrimidin-5-yl)ethanone. Researchers have employed various strategies, such as microwave-assisted synthesis and catalytic cross-coupling reactions, to optimize the production process. These methods not only enhance the yield but also ensure the purity and structural integrity of the compound, which is critical for its application in drug discovery.

The biological evaluation of 2-amino-pyrimidine derivatives has revealed promising results in preclinical studies. For instance, a study published in the journal Nature Communications demonstrated that this class of compounds exhibits potent inhibitory activity against several kinases involved in cancer progression. Specifically, 2-amino-1-(pyrimidin-5-yl)ethanone was found to selectively target oncogenic signaling pathways, leading to apoptosis in cancer cells while sparing normal cells. This selective toxicity highlights its potential as a lead compound for anti-cancer drug development.

In addition to its anti-cancer properties, 2-amino-pyrimidine derivatives have shown promise in other therapeutic areas. For example, recent research has explored their role as inhibitors of viral proteases, making them potential candidates for antiviral therapies. The ability of these compounds to modulate multiple biological targets underscores their versatility and broad applicability in medicinal chemistry.

The structural flexibility of 2-amino-pyrimidine derivatives allows for extensive chemical modifications to enhance their pharmacokinetic properties. For instance, substituent modifications at the pyrimidine ring or the amino ketone moiety can improve solubility, bioavailability, and metabolic stability. These optimizations are crucial for translating laboratory findings into clinically relevant drugs.

In conclusion, CAS No. 1211530-06-1, or 2-amino-1-(pyrimidin-5-yl)ethanone, represents a valuable addition to the portfolio of pyrimidine-based compounds with significant potential in drug discovery. Its unique structure, coupled with recent advancements in synthetic and biological research, positions it as a promising candidate for addressing unmet medical needs across various therapeutic areas.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)