• 1. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 2. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 3. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 4. An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems
  RabailGul,MariamMir,MurtazaNAli
• 5. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642

4-Chloro-2-Methylpyridin-3-Amine: A Comprehensive Overview

4-Chloro-2-Methylpyridin-3-Amine (CAS No. 1211399-74-4) is a heterocyclic aromatic compound that has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This compound, also referred to as Cl-pyridinamine, is characterized by its pyridine ring substituted with a chlorine atom at the 4-position and a methyl group at the 2-position, along with an amine group at the 3-position. The unique combination of these substituents imparts distinctive electronic and steric properties to the molecule, making it a valuable building block in various chemical syntheses and applications.

The synthesis of 4-Chloro-2-Methylpyridin-3-Amine typically involves multi-step processes that often include nucleophilic aromatic substitution or coupling reactions. Recent advancements in catalytic methods have enabled more efficient and selective pathways for its preparation. For instance, the use of palladium-catalyzed cross-coupling reactions has been reported to facilitate the construction of this compound with high yields and purity. These methods not only enhance the scalability of production but also align with green chemistry principles by minimizing waste and reducing energy consumption.

In terms of applications, 4-Chloro-2-Methylpyridin-3-Amine has found utility as an intermediate in the synthesis of bioactive compounds. Its role as a precursor in drug discovery has been particularly notable, where it serves as a key component in the development of potential therapeutic agents targeting various diseases. For example, recent studies have highlighted its use in the design of inhibitors for kinase enzymes, which are implicated in cancer progression. The compound's ability to act as a scaffold for attaching diverse functional groups makes it highly versatile in medicinal chemistry.

Moreover, 4-Chloro-2-Methylpyridin-3-Amine exhibits interesting electronic properties that make it a candidate for applications in materials science. Its conjugated aromatic system and nitrogen functionality contribute to its potential use in organic electronics, such as in the development of conductive polymers or semiconducting materials. Emerging research has explored its integration into polymer frameworks to enhance charge transport properties, paving the way for its application in advanced electronic devices.

The structural versatility of 4-Chloro-2-Methylpyridin-3-Amine also extends to its role in supramolecular chemistry. The compound's ability to form hydrogen bonds and π–π interactions makes it a promising candidate for self-assembling systems. Recent investigations have demonstrated its utility in constructing ordered nanostructures, which hold potential for applications in sensing, catalysis, and drug delivery systems.

In conclusion, 4-Chloro-2-Methylpyridin-3-Amine (CAS No. 1211399-74-4) stands out as a multifaceted compound with diverse applications across various scientific domains. Its unique chemical properties, coupled with recent advancements in synthetic methodologies and application-oriented research, underscore its significance as both a fundamental building block and a platform for innovation. As ongoing studies continue to unravel new potentials for this compound, it is poised to play an increasingly important role in advancing modern chemical sciences.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)