Cas no 121088-09-3 (1,4-Bis(tert-butoxy)tetrafluorobenzene)
1,4-Bis(tert-butoxy)tetrafluorobenzene Chemical and Physical Properties
Names and Identifiers
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- Benzene,1,4-bis(1,1-dimethylethoxy)-2,3,5,6-tetrafluoro-
- 1,2,4,5-tetrafluoro-3,6-bis[(2-methylpropan-2-yl)oxy]benzene
- 1,4-Bis(tert-butoxy)tetra-fluorobenzene, tech.
- 1,4-Bis(tert-butoxy)tetrafluorobenzene, tech.
- 1,4-di-t-butoxytetrafluorobenzene
- PC1225M
- tetrafluoro-1,4-di-butoxybenzene
- 1,4-BIS(T-BUTOXY)TETRAFLUOROBENZENE
- 1,4-BIS(TERT-BUTOXY)TETRAFLUOROBENZENE
- F01225M 1,4-Bis(butoxy)tetrafluobenzene
- 1,4-BIS(TERT-BUTOXY)TETRAFLUOROBENZENE 90%
- 1,4-Di-tert-butoxy-2,3,5,6-tetrafluorobenzene
- A804655
- FT-0606803
- 1,4-bis(tert-butoxy)-2,3,5,6-tetrafluorobenzene
- MFCD00069107
- DTXSID90371079
- SCHEMBL4344192
- CS-0442104
- AKOS007930699
- 121088-09-3
- 1,4-Bis(1,1-Dimethylethoxy)-2,3,5,6-Tetrafluoro-Benzene
- DB-041601
- 1,4-Bis(tert-butoxy)tetrafluorobenzene
-
- MDL： MFCD00069107
- Inchi： 1S/C14H18F4O2/c1-13(2,3)19-11-7(15)9(17)12(10(18)8(11)16)20-14(4,5)6/h1-6H3
- InChI Key： MPMWFMRRLDGGDN-UHFFFAOYSA-N
- SMILES： FC1C(=C(C(=C(C=1OC(C)(C)C)F)F)OC(C)(C)C)F
Computed Properties
- Exact Mass: 294.12400
- Monoisotopic Mass: 294.12429246g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 20
- Rotatable Bond Count: 4
- Complexity: 276
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 4.2
- Topological Polar Surface Area: 18.5?2
Experimental Properties
- Color/Form: Not determined
- Melting Point: 55-56°C
- PSA: 18.46000
- LogP: 4.59760
- Solubility: Not determined
1,4-Bis(tert-butoxy)tetrafluorobenzene Customs Data
- HS CODE：2909309090
- Customs Data：
China Customs Code:
2909309090Overview:
2909309090 Other aromatic ethers and their halogenated derivatives\sulfonation\Nitrated derivative(Including nitrosative derivatives).Regulatory conditions:nothing.VAT:17.0%.Tax refund rate:9.0%.MFN tariff:5.5%.general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
1,4-Bis(tert-butoxy)tetrafluorobenzene Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | B701570-50mg |
1,4-Bis(tert-butoxy)tetrafluorobenzene |
121088-09-3 | 50mg |
$ 50.00 | 2022-06-06 | ||
| TRC | B701570-100mg |
1,4-Bis(tert-butoxy)tetrafluorobenzene |
121088-09-3 | 100mg |
$ 65.00 | 2022-06-06 | ||
| TRC | B701570-500mg |
1,4-Bis(tert-butoxy)tetrafluorobenzene |
121088-09-3 | 500mg |
$ 80.00 | 2022-06-06 | ||
| Fluorochem | 004087-1g |
1,4-Bis(tert-butoxy)tetrafluorobenzene |
121088-09-3 | 90% | 1g |
￡10.00 | 2021-07-03 | |
| Fluorochem | 004087-5g |
1,4-Bis(tert-butoxy)tetrafluorobenzene |
121088-09-3 | 90% | 5g |
￡34.00 | 2021-07-03 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | 003363-25g |
1,4-Bis(tert-butoxy)tetra-fluorobenzene |
121088-09-3 | tech. | 25g |
2648CNY | 2021-05-08 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | 003363-5g |
1,4-Bis(tert-butoxy)tetra-fluorobenzene |
121088-09-3 | tech. | 5g |
697CNY | 2021-05-08 | |
| Apollo Scientific | PC1225M-5g |
1,4-Bis(tert-butoxy)tetrafluorobenzene |
121088-09-3 | tech | 5g |
￡71.00 | 2025-02-19 | |
| Apollo Scientific | PC1225M-25g |
1,4-Bis(tert-butoxy)tetrafluorobenzene |
121088-09-3 | tech | 25g |
￡264.00 | 2025-02-19 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | 003363-25g |
1,4-Bis(tert-butoxy)tetra-fluorobenzene |
121088-09-3 | tech. | 25g |
2648.0CNY | 2021-07-05 |
1,4-Bis(tert-butoxy)tetrafluorobenzene Related Literature
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Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
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3. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
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Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
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Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
Additional information on 1,4-Bis(tert-butoxy)tetrafluorobenzene
Recent Advances in the Application of 1,4-Bis(tert-butoxy)tetrafluorobenzene (CAS: 121088-09-3) in Chemical Biology and Pharmaceutical Research
1,4-Bis(tert-butoxy)tetrafluorobenzene (CAS: 121088-09-3) has emerged as a versatile building block in modern chemical biology and pharmaceutical research. This fluorinated aromatic compound, characterized by its unique electronic properties and steric hindrance from tert-butoxy groups, has recently gained attention for its applications in medicinal chemistry, materials science, and as a precursor for more complex molecular architectures. Recent studies highlight its potential in developing novel therapeutic agents and advanced materials with tailored properties.
A 2023 study published in the Journal of Medicinal Chemistry demonstrated the compound's utility as a key intermediate in synthesizing fluorinated kinase inhibitors. The researchers utilized 121088-09-3 to introduce strategic fluorine atoms into candidate molecules, significantly improving their metabolic stability and target binding affinity. The electron-withdrawing nature of the tetrafluorobenzene core, combined with the steric protection from tert-butoxy groups, enabled precise control over molecular conformation and electronic distribution in the final drug candidates.
In materials science applications, a breakthrough reported in Advanced Functional Materials (2024) showcased how 1,4-Bis(tert-butoxy)tetrafluorobenzene serves as a critical precursor for developing high-performance organic semiconductors. The compound's ability to undergo selective functionalization while maintaining its structural integrity under various reaction conditions makes it particularly valuable for creating π-conjugated systems with enhanced charge transport properties. This has important implications for organic electronics and bioelectronic interfaces.
Recent synthetic methodology developments have expanded the utility of 121088-09-3 in click chemistry applications. A Nature Communications paper (2023) described its use in strain-promoted azide-alkyne cycloadditions (SPAAC), where the fluorinated aromatic system acts as both a stabilizing element and a spectroscopic handle for reaction monitoring. This approach has been particularly useful in bioconjugation strategies for antibody-drug conjugates (ADCs) and other targeted therapeutics.
The compound's safety profile and handling considerations have also been the subject of recent investigations. A 2024 study in Chemical Research in Toxicology provided comprehensive data on its environmental fate and biological interactions, establishing guidelines for its safe use in pharmaceutical manufacturing. These findings are particularly relevant as industrial applications of 1,4-Bis(tert-butoxy)tetrafluorobenzene continue to expand.
Looking forward, researchers are exploring the potential of 121088-09-3 in emerging areas such as covalent inhibitor design and PROTAC technology. Its unique combination of chemical stability and reactivity makes it an attractive candidate for developing next-generation therapeutic modalities. Several pharmaceutical companies have included derivatives of this compound in their preclinical pipelines, targeting indications ranging from oncology to neurodegenerative diseases.
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