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  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
• 2. An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells?
  Xue-Ying Wang,Ying Pei,Min Xie,Zi-He Jin,Ya-Shi Xiao,Yang Wang,Li-Na Zhang,Yan Li,Wei-Hua Huang Lab Chip, 2015,15, 1178-1187
• 3. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 4. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 5. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
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Comprehensive Overview of 2-Bromopyrimidine-5-carboxamide (CAS No. 1209458-32-1): Properties, Applications, and Market Trends

2-Bromopyrimidine-5-carboxamide (CAS No. 1209458-32-1) is a high-value heterocyclic compound widely utilized in pharmaceutical and agrochemical research. Its molecular structure, featuring a pyrimidine core substituted with a bromine atom and a carboxamide group, makes it a versatile intermediate for synthesizing bioactive molecules. The compound's unique reactivity, particularly in cross-coupling reactions like Suzuki-Miyaura or Buchwald-Hartwig, has garnered significant attention from medicinal chemists.

Recent studies highlight the growing demand for 2-Bromopyrimidine-5-carboxamide in small-molecule drug discovery, especially for kinase inhibitors targeting oncology and inflammatory diseases. Its role as a building block in proteolysis-targeting chimeras (PROTACs)—a breakthrough technology in targeted protein degradation—has further amplified its commercial relevance. Researchers frequently search for "pyrimidine derivatives in drug design" or "bromopyrimidine synthesis optimization," reflecting industry interest in scalable production methods.

The compound's physicochemical properties—including a molecular weight of 216.02 g/mol, moderate water solubility, and stability under inert conditions—are critical for high-throughput screening applications. Analytical techniques like HPLC purity analysis and NMR spectroscopy are essential for quality control, as impurities may affect downstream reactions. Suppliers often emphasize "CAS 1209458-32-1 specifications" or "GMP-grade pyrimidine intermediates" to address stringent regulatory requirements in API manufacturing.

From an industrial perspective, the global market for 2-Bromopyrimidine-5-carboxamide is projected to grow at a CAGR of 6.8% (2023–2030), driven by increased R&D investment in precision medicine. Sustainable synthesis routes, such as catalytic bromination or flow chemistry approaches, are emerging trends to reduce environmental impact. FAQs like "how to store bromopyrimidine derivatives" or "alternative reagents for carboxamide functionalization" indicate user concerns about practical handling and cost-efficiency.

In conclusion, 2-Bromopyrimidine-5-carboxamide exemplifies the intersection of structural diversity and functional adaptability in modern organic chemistry. Its applications span from bioconjugation probes to crystallography studies, with ongoing innovations in chemoinformatics accelerating its adoption. As patent landscapes evolve, this compound remains a focal point for both academic and industrial research communities.

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