Cas no 1208313-37-4 (3-Chloro-5-fluoro-4-methylphenylboronic acid)
3-Chloro-5-fluoro-4-methylphenylboronic acid is a boronic acid derivative widely used as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the synthesis of complex biaryl structures. Its halogen-substituted aromatic ring enhances reactivity and selectivity in palladium-catalyzed transformations, making it valuable for pharmaceutical and agrochemical applications. The presence of both chloro and fluoro substituents, along with the methyl group, offers steric and electronic modulation for tailored coupling efficiency. This compound exhibits good stability under standard handling conditions and is compatible with a range of solvents and reagents. Its high purity and reliable performance make it a preferred choice for research and industrial-scale synthesis.
1208313-37-4 structure
Product Name:3-Chloro-5-fluoro-4-methylphenylboronic acid
CAS No:1208313-37-4
MF:C7H7BClFO2
MW:188.391684770584
CID:5003565
Update Time:2025-06-07
3-Chloro-5-fluoro-4-methylphenylboronic acid Chemical and Physical Properties
Names and Identifiers
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- 3-Chloro-5-fluoro-4-methylphenylboronic acid
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- Inchi: 1S/C7H7BClFO2/c1-4-6(9)2-5(8(11)12)3-7(4)10/h2-3,11-12H,1H3
- InChI Key: HCIXNKOVNHJHPS-UHFFFAOYSA-N
- SMILES: ClC1C=C(B(O)O)C=C(C=1C)F
Computed Properties
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 12
- Rotatable Bond Count: 1
- Complexity: 158
- Topological Polar Surface Area: 40.5
3-Chloro-5-fluoro-4-methylphenylboronic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Alichem | A010011422-250mg |
3-Chloro-5-fluoro-4-methylphenylboronic acid |
1208313-37-4 | 97% | 250mg |
$480.00 | 2023-09-04 | |
| Alichem | A010011422-500mg |
3-Chloro-5-fluoro-4-methylphenylboronic acid |
1208313-37-4 | 97% | 500mg |
$790.55 | 2023-09-04 | |
| Alichem | A010011422-1g |
3-Chloro-5-fluoro-4-methylphenylboronic acid |
1208313-37-4 | 97% | 1g |
$1475.10 | 2023-09-04 |
3-Chloro-5-fluoro-4-methylphenylboronic acid Related Literature
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Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
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A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
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Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
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Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
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