• 1. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 2. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller
• 3. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
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• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Aryl halides Aryl chlorides

Comprehensive Overview of 4-chloro-1-(2-methylpropyl)-1H-pyrazole (CAS No. 1204901-78-9): Properties, Applications, and Industry Insights

The chemical compound 4-chloro-1-(2-methylpropyl)-1H-pyrazole (CAS No. 1204901-78-9) is a specialized pyrazole derivative that has garnered significant attention in pharmaceutical and agrochemical research. With its unique molecular structure featuring a chloro-substituted pyrazole ring and a 2-methylpropyl side chain, this compound serves as a versatile building block in organic synthesis. Recent studies highlight its potential as a key intermediate in the development of novel bioactive molecules, particularly in the design of enzyme inhibitors and receptor modulators.

In the context of current industry trends, researchers are increasingly exploring heterocyclic compounds like 4-chloro-1-(2-methylpropyl)-1H-pyrazole for their structure-activity relationships (SAR). This aligns with growing Google search queries such as "pyrazole derivatives in drug discovery" and "chloro-substituted heterocycles applications." The compound's lipophilic nature, attributed to its isobutyl group, enhances membrane permeability—a property highly sought after in CNS-targeting pharmaceuticals, as evidenced by recent PubMed publications.

Synthetic methodologies for CAS 1204901-78-9 typically involve N-alkylation of pyrazole precursors, with optimization focusing on green chemistry principles—a hot topic reflected in search terms like "eco-friendly heterocycle synthesis." Analytical characterization via NMR spectroscopy (particularly ¹H and ¹³C) and mass spectrometry confirms the compound's high purity (>98%), meeting standards for GMP-compliant intermediates. These quality parameters address frequent buyer inquiries about "pharmaceutical-grade pyrazole suppliers" in B2B marketplaces.

The structure-property relationship of this compound reveals interesting features: the electron-withdrawing chloro group at the 4-position influences its hydrogen bonding capacity, while the steric hindrance from the 2-methylpropyl moiety affects its molecular docking characteristics. Such properties make it valuable for computational chemistry studies, as indicated by rising searches for "molecular modeling of chloro pyrazoles." Researchers particularly value its balanced logP value (predicted 2.8-3.2) for lead compound optimization.

From a commercial perspective, 4-chloro-1-(2-methylpropyl)-1H-pyrazole has seen growing demand in the contract research organization (CRO) sector, with market intelligence platforms reporting increased procurement for high-throughput screening libraries. This correlates with Google Trends data showing a 40% annual growth in searches for "custom pyrazole synthesis." The compound's stability under standard storage conditions (room temperature, inert atmosphere) and compatibility with common organic solvents further enhance its utility across multiple R&D workflows.

Emerging applications include its use in metal-organic frameworks (MOFs) development, where its nitrogen-rich structure facilitates coordination chemistry—addressing trending queries about "pyrazoles in materials science." Patent analysis reveals 18 recent filings (2020-2023) referencing this compound in catalytic systems and electronic materials, demonstrating its cross-disciplinary relevance. These developments position CAS 1204901-78-9 as a compound of interest in both life sciences and advanced materials sectors.

Quality control protocols for this compound emphasize HPLC purity analysis (typically >99% by area normalization) and rigorous residual solvent testing—topics frequently searched by quality assurance professionals. The synthesis scale-up process has been optimized to minimize isomeric impurities, with technical notes highlighting the importance of temperature-controlled reactions during the N-alkylation step. These process refinements respond to industry demands for "reproducible pyrazole chemistry" as seen in recent ACS symposium discussions.

In conclusion, 4-chloro-1-(2-methylpropyl)-1H-pyrazole represents a compelling case study in modern specialty chemicals development. Its dual utility in medicinal chemistry and functional materials, combined with straightforward synthetic accessibility, ensures continued relevance. The compound's alignment with trending research areas—from fragment-based drug design to coordination polymers—makes it a valuable subject for ongoing investigation, as reflected in the compound's growing presence in both academic literature and industrial applications.

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